ReviewGreen chemistry : an international journal and green chemistry resource : GC2025
Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond.
Review in Green chemistry : an international journal and green chemistry resource : GC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Film-Forming Gels for Topical Drug Delivery: A Systematic Review of the Effects of Formulation on Film Performance, Drug Release, and Skin Permeation.Drug design, development and therapy · 2026Pooled it
- Molecular Evaluation of Deep Eutectic Solvents for Wet Algae Lipid Extraction and Biofuel Production.ACS omega · 2026Article
- Activity-Coefficient-Guided Heuristics for Deep Eutectic Solvent Fractionation of Kraft Lignin.ACS omega · 2026Article
- Amazonian Nanobioeconomy 5.0: A Critical Integrative Review and Conceptual Framework Toward a Just Planetary Transition.Molecules (Basel, Switzerland) · 2026Review
- Are Microextraction Techniques Truly Green? A Critical Assessment of Green Sample Preparation Practices.Journal of separation science · 2026Review
- Valorization of Garlic (Molecules (Basel, Switzerland) · 2026Article
- Recent Advances in the Use of Natural Deep Eutectic Solvents for Natural Product Sample Preparation: Focus on Purification, Characterization, and Sustainability.Journal of separation science · 2026Review
- Effectiveness of Natural Deep Eutectic Solvents (NADES) in Extracting Bioactive Compounds fromACS omega · 2026Article
- Supramolecular Deep Eutectic Solvents as a Janus Green Platform: Integrating Curcuminoid Extraction and Biopolymer.Molecules (Basel, Switzerland) · 2026Article
- Development of mt-NADES Beads and Optimization for Efficient Extraction of Methylene Blue Using Response Surface Method.ACS omega · 2026Article
- Hydrophobic NADES-Derived Pumpkin Carotenoid Extract Attenuates Oxidative Stress and Mitochondrial Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity.Pharmaceutics · 2026Article
- Excess Properties of Aqueous Dilutions of Ammonium- and Phosphonium-Based Deep Eutectic Solvents.Journal of chemical and engineering data · 2026Article
- Crustacean and Mollusc Shell Proteins: Origin, Structure, and Functionality.Journal of food science · 2026Review
- Natural Colorants From Amazonian Plants: Bioactive Potential and Sustainable Extraction Techniques-A Review.Food science & nutrition · 2026Article
- Recent Developments in Sustainable Solubilization.ChemSusChem · 2026Article
- Volatile Natural Deep Eutectic Solvents (VNADESs) for Extraction of Shikonin Derivatives fromMolecules (Basel, Switzerland) · 2026Article
- Recent Advances in NADES-Assisted Process Intensification Technologies for Sustainable Recovery of Microalgal Bioactives: Challenges and Future Prospectives.Marine drugs · 2026Review
- Integrating green synthesis and liquid-liquid extraction of lidocaine in deep eutectic solvents.RSC medicinal chemistry · 2026Article
- Unlocking the Potential of Natural Deep Eutectic Solvents for the Valorization of Different Biological Materials.Molecules (Basel, Switzerland) · 2026Article
- Cobalt-Based Catalysts for Electrochemical Water Splitting: Harnessing the Power of Ionic Liquids and Deep Eutectic Solvents.ChemistryOpen · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Composed of various biosourced metabolites, NaDES offer significant economic, health, and environmental benefits. Their remarkable ability to interact with target compounds through non-covalent bonds enhances their versatility. As solvents, excipients, cofactors, catalysts, solubilisation promoters, stabilisers, and absorption agents, NaDES provide distinct advantages over conventional substances and can even act as active compounds themselves. Furthermore, their role in advancing innovative synthesis and formulation strategies, particularly in nanotechnology and biotechnology, is driving research in these areas. This review is the first to explore all the potential applications of NaDES in the pharmaceutical industry, while taking a comprehensive look at the theory behind them. It gives a precise definition of NaDES and describes their composition, characteristics, molecular interactions, preparation, stability and recovery. It presents detailed applications in pharmaceutical synthesis, extraction and formulation, and discusses roles as active compounds or tools for innovation. Using green metrics, the efficiency of routes including NaDES is compared to that of conventional processes. Lastly, this review addresses often overlooked points such as toxicity and process limitations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.