Trial reportBMC neurology2025
Effects of exoskeleton rehabilitation robot training on neuroplasticity and lower limb motor function in patients with stroke.
Trial report in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07057700 (Investigating the Mechanisms of Welwalk Robot in Restoring Motor Function of the Lower Extremities in Stroke Patients), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Mechanisms of Welwalk Robot in Restoring Motor Function of the Lower Extremities in Stroke Patients
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of non-pharmacological interventions for lower limb motor impairment in post-stroke hemiplegia: a systematic review and Bayesian network meta-analysis.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Application of lower limb exoskeleton robots in elderly patients with ICU-acquired weakness: a prospective clinical study.BMC geriatrics · 2026Trial
- Effect of robot-assisted gait training combined with electroacupuncture on lower limb motor function and brain network characteristics in stroke: an EEG study.Journal of neuroengineering and rehabilitation · 2025Trial
- tDCS synchronous robotic training on lower-limb with post-stroke hemiplegia: a comparative study between synchronous and sequential group.Annals of medicine · 2026Article
- Mechatronic Design and Development of a Lower-Limb Exoskeleton System Based on Knee Joint Biomechanical Principles Using Electro-Pneumatic Actuation with an Embedded EMG Controller for Experimental Validation in Elderly Gait Rehabilitation Support.Bioengineering (Basel, Switzerland) · 2026Article
- Recent research on rehabilitation interventions for post-stroke gait and balance in low- and middle-income countries: a scoping review.BMC health services research · 2026Article
- Smart exoskeleton-assisted rehabilitation after fracture surgery: closed-loop control, personalized load management, and integrated telemonitoring.Frontiers in bioengineering and biotechnology · 2026Review
- Priming iTBS for lower limb rehabilitation after stroke: Protocol for a randomized controlled trial on efficacy and neuroplasticity.PloS one · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
backgroundLower limb exoskeleton rehabilitation robot is a new technology to improve the lower limb motor function of stroke patients. Recovery of motor function after stroke is closely related to neuroplasticity in the motor cortex and associated motor areas. However, few studies investigate how rehabilitation robots affect the neuroplasticity of stroke patients.This study sought to determine the effects of lower limb exoskeleton robot walking training on neuroplasticity and lower limb motor function in patients with stroke.
methodsA total of 25 (50.26 ± 11.42 years, 68.0% male) patients(age 18-75 years, onset between 2 weeks and 6 months) with a stable condition after having a stroke were randomized into a treatment (n = 13) and control group (n = 12). Bilateral Exoskeletal Assistive Robot H1 (BEAR-H1) walking training was provided to the treatment group, whereas conventional walking training was provided to the control group. Both groups completed two training sessions per day for 30 min each and were trained 5 days a week for 4 weeks. Transcranial magnetic stimulation, Fugl-Meyer Assessment lower extremity, Functional Ambulation Category 6-min walking distance test, intelligent gait analysis, and surface electromyography of the lower limbs were performed before and 4 weeks after treatment.
resultsBoth groups showed obvious improvements in all evaluation indicators (p < 0.05). Compared with the control group, the treatment group exhibited a decreased resting motor threshold and increased motor-evoked potential amplitude and recruitment curve slope (p < 0.05). The treatment group performed better than the control group (p < 0.05) in the 6-min walk test and knee flexion co-contraction ratio (CR). Correlation analysis showed that resting motor threshold, motor-evoked potential amplitude, and the recruitment curve slope were significantly correlated with the 6-min walk test, CR on ankle dorsiflexion, the root mean square of the tibialis anterior, biceps femoris, and medial gastrocnemius (p < 0.05).
conclusionWalking training using the bilateral exoskeletal assistive robot H1 improved cerebral cortical excitability in patients with stroke, which facilitated changes in neuroplasticity and enhanced lower limb motor function. REGISTRATION: Chinese Clinical Trail Registry: ChiCTR1900028262. Registered Date: December 16,2019. Registration-URL: http://www.chictr.org.cn.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.