Evidence map›Paper›PMID 40002386›Full record

ReviewAntioxidants (Basel, Switzerland)2025

Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses-A Narrative Review.

Luca De Rossi, Gabriele Rocchetti, Luigi Lucini, Annalisa Rebecchi

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Integrated Chemical Profiling and Biological Assessment ofAntibiotics (Basel, Switzerland) · 2026
    Article
  17. Article
  18. Multi-Target Bioactivity ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  19. Article
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luca De RossiDepartment for Sustainable Food Process (DiSTAS), Università Cattolica del Sacro Cuore, Via Stefano Leonida Bissolati 74, 26100 Cremona, Italy.
Gabriele RocchettiDepartment of Animal Science, Food and Nutrition, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy.ORCID 0000-0003-3488-4513
Luigi LuciniDepartment for Sustainable Food Process, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy.ORCID 0000-0002-5133-9464
Annalisa RebecchiDepartment for Sustainable Food Process (DiSTAS), Università Cattolica del Sacro Cuore, Via Stefano Leonida Bissolati 74, 26100 Cremona, Italy.ORCID 0000-0003-0109-4363

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyphenols (PPs) are recognized as bioactive compounds and antimicrobial agents, playing a critical role in enhancing food safety, preservation, and extending shelf life. The antimicrobial effectiveness of PPs has different molecular and biological reasons, predominantly linked to their hydroxyl groups and electron delocalization, which interact with microbial cell membranes, proteins, and organelles. These interactions may reduce the efficiency of metabolic pathways, cause destructive damage to the cell membrane, or they may harm the proteins and nucleic acids of the foodborne bacteria. Moreover, PPs exhibit a distinctive ability to form complexes with metal ions, further amplifying their antimicrobial activity. This narrative review explores the complex and multifaceted interactions between PPs and foodborne pathogens, underlying the correlation of their chemical structures and mechanisms of action. Such insights shed light on the potential of PPs as innovative natural preservatives within food systems, presenting an eco-friendly and sustainable alternative to synthetic additives.

Indexed as

antimicrobial activityantioxidantsfoodborne pathogensplant extractspolyphenols

Identifiers

PMID40002386
PMCPMC11851925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.