ArticleMetabolites2025
Heat Tolerance Differences Between Hu Sheep and Hu Crossbred Sheep in Microbial Community Structure and Metabolism.
Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Seasonal heat stress effects on the physiological, hematological, hormonal and biochemical responses of Tunisian sheep breeds.Tropical animal health and production · 2026Article
- Thiamine modulates the mammary inflammation, antioxidant function and lactation performance in lactating sheep under heat-stress conditions.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Proteomics- and Metabolomics-Based Investigation of the Effects ofAnimals : an open access journal from MDPI · 2026Article
- Effects of Summer Heat Stress on Physiological Parameters and Reproductive Efficiency of Barbarine Ewes Under Natural Outdoor or Indoor Conditions.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Comparative Skin Transcriptome Analysis Identifies Candidate Genes Associated with Skin Responses in Hu Sheep Raised Under Different Regional Rearing Conditions.Animals : an open access journal from MDPI · 2026Article
- Rumen-Protected Taurine Alleviates Heat Stress Injury in Hu Sheep by Regulating Inflammatory Response, Gut Microbiota and Transcriptome.Animals : an open access journal from MDPI · 2026Article
- A Follow-Up Study on Testicular Cellular and Transcriptomic Responses to Mild Scrotal Heat Stress in Wugu-Hu and Hu Rams.Animals : an open access journal from MDPI · 2026Article
- Effects of Sheltering Conditions on Serum Biochemical and Stress Hormone Profiles of Lamb During Cold Exposure.Animals : an open access journal from MDPI · 2026Article
- Article
- NaCl-Supplemented Alfalfa-Based TMR Improves Meat Quality by Enhancing Essential Amino Acids and Optimizing Fatty Acid Profile in AOHU Sheep Under Simulated Saline-Alkaline Conditions.Foods (Basel, Switzerland) · 2025Article
- Impact of Heat Stress on Ovarian Function and circRNA Expression in Hu Sheep.Animals : an open access journal from MDPI · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe frequent occurrence of extreme temperature events causes significant economic losses to the livestock industry. Therefore, delving into the differences in the physiological and molecular mechanisms of heat stress across different sheep breeds is crucial for developing effective management and breeding strategies.
methodsThis study explores the differences in heat tolerance mechanisms between Hu sheep and Xinggao sheep by comparing their growth performance under normal and heat stress conditions, as well as examining the differences in physiological, biochemical, and antioxidant indicators related to heat tolerance, serum metabolomics, and gut microbiomics in a heat stress environment.
resultsThe results indicate that with changes in the temperature-humidity index (THI), Hu sheep exhibit superior stability in respiratory rate (RR) and rectal temperature (RT) fluctuations compared to Xinggao sheep. In terms of biochemical indicators and antioxidant capacity, the levels of creatinine (Cr) and superoxide dismutase (SOD) in Hu sheep serum are significantly higher than those in Xinggao sheep. In comparison, alkaline phosphatase (ALP) and malondialdehyde (MDA) levels are significantly lower. Metabolomic results showed that, compared to Hu sheep, Xinggao sheep exhibited higher cortisol (COR) and dopamine (DA) levels under heat stress conditions, a stronger lipid mobilization capacity, and elevated levels of tricarboxylic acid (TCA) cycle-related metabolites. Furthermore, gut microbiome analysis results indicate that Hu sheep demonstrate stronger cellulose degradation capabilities, as evidenced by significantly higher abundances of microorganisms such as
conclusionsIn summary, Hu sheep exhibit stronger heat tolerance compared to Xinggao sheep. These findings provide an important theoretical basis for the breeding and selection of heat-tolerant meat sheep varieties and offer strong support for the region's livestock industry in addressing the challenges posed by global warming.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.