Evidence map›Paper›PMID 39584955›Full record

ReviewJournal of xenobiotics2024

Additives in Processed Foods as a Potential Source of Endocrine-Disrupting Chemicals: A Review.

Anand Paramasivam, Rajadurai Murugan, Mathew Jeraud, Angel Dakkumadugula, Ravisankar Periyasamy, Selvam Arjunan

Abstract readReview
In one paragraph

Review in Journal of xenobiotics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anand ParamasivamDepartment of Physiology, RVS Dental College and Hospital (Affiliated to The Tamil Nadu Dr. M.G.R. Medical University, Chennai 600032, Tamil Nadu, India), Kumaran Kottam Campus, Kannampalayan, Coimbatore 641402, Tamil Nadu, India.ORCID 0000-0002-2626-6910
Rajadurai MuruganDepartment of Food Technology, Faculty of Life and Allied Health Sciences, M S Ramaiah University of Applied Sciences, Bangalore 560054, Karnataka, India.
Mathew JeraudDepartment of Physiology, Ibn Sina National College for Medical Studies, Jeddah 22421, Saudi Arabia.
Angel DakkumadugulaClinical Division, Indian Council of Medical Research-National Institute of Nutrition, Hyderabad 500007, Telangana, India.
Ravisankar PeriyasamyDepartment of Anatomy, SRM Dental College, SRM Institute of Science and Technology, Bharathi Salai, Ramapuram Campus, Chennai 600089, Tamil Nadu, India.ORCID 0000-0002-5600-8365
Selvam ArjunanLerner Research Institute, Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Processed foods, accounting for most consumable food categories today, contain considerable amounts of food additives. Food additives are substances added to food products to improve taste, consistency, appearance, or shelf life. Various food additives, such as phthalates, bisphenol A, tartrazine, erythrosine, artificial sweeteners, and parabens, have been identified as potential sources of endocrine-disrupting chemicals (EDCs) in processed foods. EDCs are substances that frequently interfere with the regular functioning of the endocrine system, creating an unusual environment in the biological system, which leads to adverse health effects such as the disruption of hormone synthesis, receptor binding, and signal transduction pathways, as well as energy metabolic homeostatic disorders which potentially increasing the risk of obesity, type-2 diabetes, cardiometabolic diseases and may also trigger allergic reactions. Consequently, they can also impact mammary gland development, and reproductive function, further leading to developmental abnormalities. This review aims to insights into the various food additives that act as potential endocrine-disrupting chemicals (EDCs) and to describe their applications in the food industry, as well as the failure of hormonal homeostatic mechanisms, which eventually result in hazardous health effects. It also outlines strategies to reduce the use of food additives and suggests alternative additives with minimal or no endocrine-disrupting properties, highlighting their importance for maintaining human health.

Indexed as

developmental effectsendocrine-disrupting chemicalsfood additivesgene expressionreceptor bindingthyroid dysfunction

Identifiers

PMID39584955
PMCPMC11587131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.