ArticleNature2024
Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Ixekizumab With or Without Tirzepatide in Adults With Psoriasis and Overweight or Obesity: A Phase 3b Randomized Clinical Trial.JAMA dermatology · 2026Trial
- Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application.MedComm · 2026Review
- An IL-1, IL-17, and IL-22 cytokine circuit controls vulvovaginal candidiasis independently of estrogen.PLoS pathogens · 2026Article
- [Gut-brain-joint axis in rheumatoid arthritis: from microeco-logical disturbance to multi-target synergy].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response.Nature communications · 2026Article
- Structural immunity: immune cells as architects of tissue barriers.Nature reviews. Immunology · 2026Review
- Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome.Nature metabolism · 2026Article
- Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection.Immunity, inflammation and disease · 2026Review
- Night-restricted feeding preserves the ovarian circadian rhythm of IL-17 and promotes follicular development in prepubertal and pubertal rabbits.Journal of ovarian research · 2026Article
- Circadian clock and cancer.Military Medical Research · 2026Review
- Targeting IL-17 Presents a Promising Strategy for Treating Diseases Related to the Dysregulation of Lipid Homeostasis.Mediators of inflammation · 2026Review
- Integrated bulk and single-cell transcriptomics to develop an efferocytosis-related prognostic model for lung adenocarcinoma and validate the key gene LDHA.European journal of medical research · 2025Article
- Dual roles of T cells in metabolic dysfunction-associated steatohepatitis pathogenesis and liver fibrosis: From inflammation to therapeutic targets.Hepatology communications · 2025Review
- Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment.Gut microbes · 2025Review
- Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Relationship between shift scheduling, sleep knowledge and sleep quality in medical trainees: protocol for a global cross-sectional survey.Journal of thoracic disease · 2025Article
- Immune system influence on physiology.Science (New York, N.Y.) · 2025Review
- Ticking clocks and tamed transplants: how circadian timing rewrites graft-versus-host disease outcomes.Signal transduction and targeted therapy · 2025Article
- NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection.Nature metabolism · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Aaron DouglasSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0002-8812-9575
Brenneth StevensSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Miguel RendasChampalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.
Harry KaneSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Evan LynchSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0009-0005-3577-4131
Britta KunkemoellerBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Karl Wessendorf-RodriguezMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Emily A DaySchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0003-3245-5715
Caroline SuttonSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Martin BrennanSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Katie O'BrienSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Ayano C KohlgruberBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hannah PrendevilleSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0003-3731-4372
Amanda E GarzaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8557-8765
Luke A J O'NeillSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0002-4333-2748
Kingston H G MillsSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Christian M MetalloMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0003-2404-3040
Henrique Veiga-FernandesChampalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.
Lydia LynchSchool of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland. lydialynch@princeton.edu.ORCID 0000-0002-4273-4681
Funding
Supplement: Immunometabolic and epigenetic effects of obesity on innate immune surveillance in cancerR01AI134861 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LYNCH, LYDIA · 2018 to 2022
$2.9MComprehensive Lab Animal Monitor System (CLAMS) for the Study of Mouse MetabolismS10OD020100 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI BANKS, ALEXANDER · 2015 to 2015
$419kNIAID NIH HHS R01 AI134861NIH HHS S10 OD020100
Abstract
The circadian rhythm of the immune system helps to protect against pathogens
Indexed as
Adipose TissueCircadian RhythmHomeostasisInterleukin-17LipogenesisReceptors, Antigen, T-Cell, gamma-deltaAnimalsARNTL Transcription FactorsBiological ClocksBody TemperatureInterferon-gammaLeukocyte Common AntigensMaleMiceMice, Inbred C57BLNuclear Receptor Subfamily 1, Group F, Member 3ARNTL Transcription FactorsBmal1 protein, mouseIl17a protein, mouseInterferon-gammaInterleukin-17Leukocyte Common AntigensNuclear Receptor Subfamily 1, Group F, Member 3Ptprc protein, mouseReceptors, Antigen, T-Cell, gamma-deltaReceptors, Interleukin-17Rorc protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.