Evidence map›Paper›PMID 39440976›Full record

ArticlemBio2024

Fpa (YlaN) is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in

Jeffrey M Boyd, Kylie Ryan Kaler, Karla Esquilín-Lebrón, Ashley Pall, Courtney J Campbell, Mary E Foley, Gustavo Rios-Delgado, Emilee M Mustor, Timothy G Stephens, Hannah Bovermann and 8 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. The phenotypic landscape of the model firmicuteProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025
    Review
  8. Article
  9. Linking Virulence and Iron Limitation Response inJournal of proteome research · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Analysis of genetic requirements and nutrient availability forbioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Article
  17. ThebioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jeffrey M BoydDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.ORCID 0000-0001-7721-3926
Kylie Ryan KalerDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
Karla Esquilín-LebrónDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
Ashley PallDepartment of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan, USA.
Courtney J CampbellDepartment of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan, USA.
Mary E FoleyDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
Gustavo Rios-DelgadoDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.ORCID 0000-0002-9304-6344
Emilee M MustorDepartment of Molecular Biosciences, University of South Florida, Tampa, Florida, USA.
Timothy G StephensDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.ORCID 0000-0003-1554-7175
Hannah BovermannDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
Todd M GrecoDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Ileana M CristeaDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0002-6533-2458
Valerie J CarabettaDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey, USA.ORCID 0000-0002-2211-0556
William N BeaversDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-0285-7775
Debashish BhattacharyaDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-5094-8105
Lindsey N ShawDepartment of Molecular Biosciences, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-0629-8990
Timothy L StemmlerDepartment of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan, USA.ORCID 0000-0002-6298-088X

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Mechanisms of cellular respiration-dependent cell lysis and its impact on biofilm formation and disassembly in Staphylococcus aureus.R01AI139100 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI BOYD, JEFF M · 2018 to 2022
$1.9M
The Role and Regulation of Extracellular Proteases in Staphylococcus aureusR01AI124458 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2017 to 2020
$1.7M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI124458HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI139100National Science Foundation (NSF) 1750624NIAID NIH HHS R01 AI124458NIAID NIH HHS R01 AI139100NIDDK NIH HHS P30 DK058404U.S. Department of Agriculture (USDA) NE-2248
6 · The paper itself

Abstract

Iron (Fe) is a trace nutrient required by nearly all organisms. As a result of the demand for Fe and the toxicity of non-chelated cytosolic ionic Fe, regulatory systems have evolved to tightly balance Fe acquisition and usage while limiting overload. In most bacteria, including the mammalian pathogen

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialIronRepressor ProteinsStaphylococcus aureusHomeostasisIron-Binding ProteinsBacterial Proteinsferric uptake regulating proteins, bacterialIronIron-Binding ProteinsRepressor ProteinsFpaFurironStaphylococcus aureussulfurYlaN

Identifiers

PMID39440976
PMCPMC11559061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.