Evidence map›Paper›PMID 39215998›Full record

ArticleCell reports2024

Trigeminal innervation and tactile responses in mouse tongue.

Linghua Zhang, Maximilian Nagel, William P Olson, Alexander T Chesler, Daniel H O'Connor

Abstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Peripheral mechanisms of tactile sensation in fish.Current opinion in neurobiology · 2026
    Review
  5. Anatomical Characteristics of Tongue-Innervating Mechanoreceptors.The Journal of comparative neurology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Developing and regenerating a sense of taste.Current topics in developmental biology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Linghua ZhangSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.
Maximilian NagelSensory Cells and Circuits Section, National Center for Complementary and Integrative Health, Bethesda, MD 20892, USA.
William P OlsonSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.
Alexander T CheslerSensory Cells and Circuits Section, National Center for Complementary and Integrative Health, Bethesda, MD 20892, USA.
Daniel H O'ConnorSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA. Electronic address: dan.oconnor@jhmi.edu.

Funding

Norepinephrine modulation of neocortex during flexible behaviorR01NS104834 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV, O'CONNOR, DANIEL HANS · 2018 to 2022
$4.1M
Functions of locus coeruleus norepinephrine neurons in decision making across multiple timescalesRF1NS131984 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV, O'CONNOR, DANIEL HANS · 2023 to 2023
$2.3M
Circuit and cellular dynamics in mouse cortex during tactile detectionR01NS089652 · NINDS · JOHNS HOPKINS UNIVERSITY · PI O'CONNOR, DANIEL HANS · 2014 to 2019
$2.1M
NINDS NIH HHS R01 NS089652NINDS NIH HHS R01 NS104834NINDS NIH HHS RF1 NS131984
6 · The paper itself

Abstract

The neural basis of tongue mechanosensation remains largely mysterious despite the tongue's high tactile acuity, sensitivity, and relevance to ethologically important functions. We studied terminal morphologies and tactile responses of lingual afferents from the trigeminal ganglion. Fungiform papillae, the taste-bud-holding structures in the tongue, were convergently innervated by multiple Piezo2

Indexed as

MechanoreceptorsTongueTrigeminal GanglionAnimalsMaleMiceMice, Inbred C57BLTaste BudsTouchCP: NeuroscienceLTMRmechanoreceptorsomatosensationtaste budtonguetouchtrigeminaltrigeminal ganglion

Identifiers

PMID39215998
PMCPMC11500437

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.