Evidence map›Paper›PMID 38671253›Full record

ArticleThe EMBO journal2024

Functional and structural insights into activation of TRPV2 by weak acids.

Ferdinand M Haug, Ruth A Pumroy, Akshay Sridhar, Sebastian Pantke, Florian Dimek, Tabea C Fricke, Axel Hage, Christine Herzog, Frank G Echtermeyer, Jeanne de la Roche and 6 more

Open access · diamondAbstract read
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Lysophosphatidylcholine sensitizes TRPV2 by indirect mechanisms.Pflugers Archiv : European journal of physiology · 2025
    Article
  10. Article
  11. Determinants for Activation of the Ion Channel TRPV3 by Weak Acids.International journal of molecular sciences · 2025
    Article
  12. Article
  13. Article
  14. Structural insights into TRPV2 modulation by probenecid.Nature structural & molecular biology · 2025
    Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Ferdinand M Haug *Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany.
Ruth A Pumroy *Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Akshay SridharDepartment of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
Sebastian PantkeDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0002-4935-4390
Florian DimekDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany.
Tabea C FrickeDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany.ORCID http://orcid.org/0009-0002-0958-1895
Axel HageDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany.
Christine HerzogDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany.
Frank G EchtermeyerDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany.
Jeanne de la RocheInstitute for Neurophysiology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0001-5753-1732
Adrian KohThermo Fisher Scientific, Eindhoven, The Netherlands.
Abhay KotechaThermo Fisher Scientific, Eindhoven, The Netherlands.
Rebecca J HowardDepartment of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2049-3378
Erik LindahlDepartment of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
Vera Moiseenkova-BellDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. vmb@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-0589-4053
Andreas LefflerDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany. leffler.andreas@mh-hannover.de.ORCID http://orcid.org/0000-0003-1121-6387
Medizinische Hochschule Hannover · DEStockholm University · SEThermo Fisher Scientific (Netherlands) · NLTranslational Therapeutics (United States) · USScience for Life Laboratory · SE

Funding

Structural Insights into TRPV Channel GatingR01GM103899 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOISEENKOVA-BELL, VERA · 2013 to 2021
$3.2M
Molecular mechanisms of TRPV5 gatingR01GM129357 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOISEENKOVA-BELL, VERA · 2018 to 2021
$1.7M
Alida Gehrke-Stiftung n.d.BioExcel Center of Excellence EU-823830Foundation for the National Institutes of Health (FNIH) R01GM103899Foundation for the National Institutes of Health (FNIH) R01GM129357Marie-Sklodowska-Curie Grant 898762Swedish Research Council 2019-02433,2021-05806
6 · The paper itself

Abstract

Transient receptor potential (TRP) ion channels are involved in the surveillance or regulation of the acid-base balance. Here, we demonstrate that weak carbonic acids, including acetic acid, lactic acid, and CO

Indexed as

TRPV Cation ChannelsAcidsAnimalsCalciumCryoelectron MicroscopyHEK293 CellsHumansMolecular Dynamics SimulationPatch-Clamp TechniquesRatsAcidsCalciumTRPV2 protein, humanTrpv2 protein, ratTRPV Cation ChannelsAcidosisCryo-EMModulation SiteProtonsTransient Receptor Channel V2

Identifiers

PMID38671253
PMCPMC11148119
OpenAlexW4395665310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.