Evidence map›Paper›PMID 38338515›Full record

ArticleFoods (Basel, Switzerland)2024

Effect of Conventional Humid-Dry Heating through the Maillard Reaction on Chemical Changes and Enhancement of In Vitro Bioactivities from Soy Protein Isolate Hydrolysate-Yeast Cell Extract Conjugates.

Rewat Phongphisutthinant, Pairote Wiriyacharee, Kongsak Boonyapranai, Sakaewan Ounjaijean, Sirinya Taya, Pornsiri Pitchakarn, Pattavara Pathomrungsiyounggul, Patamaphorn Utarat, Worachai Wongwatcharayothin, Chalermkwan Somjai and 1 more

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Conjugation ofPharmaceutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Rewat PhongphisutthinantMultidisciplinary Research Institute, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0003-1038-176X
Pairote WiriyachareeResearch Center of Microbial Diversity and Sustainable Utilization, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-7052-0779
Kongsak BoonyapranaiResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0003-1429-7709
Sakaewan OunjaijeanResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0001-9067-2051
Sirinya TayaMultidisciplinary Research Institute, Chiang Mai University, Chiang Mai 50200, Thailand.
Pornsiri PitchakarnFaculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-6219-386X
Pattavara PathomrungsiyounggulFaculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.
Patamaphorn UtaratFaculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.
Worachai WongwatcharayothinFaculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.ORCID 0000-0003-4290-7201
Chalermkwan SomjaiProcessing and Product Development Factory, The Royal Project Foundation, Chiang Mai 50100, Thailand.ORCID 0000-0002-0347-4979
Supakit ChaipootMultidisciplinary Research Institute, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-9817-306X
Chiang Mai University · THRoyal Project Foundation · TH

Funding

Chiang Mai University This research is supported by Fundamental Fund 2022, Chiang Mai University, Thailand.
6 · The paper itself

Abstract

This study investigated the formation of soy protein isolate hydrolysate-yeast cell extract (SPIH-YCE) conjugates through a humid-dry heating process and their impact on bioactivity. The incubation of SPIH-YCE samples at 60 °C and ~75% humidity for varying durations (0, 5, 10, 15, and 20 days) resulted in a significant decrease in reducing sugars and free amino acids, while the degree of glycation increased by approximately 65.72% after 10 days. SDS-PAGE analysis and size exclusion chromatography revealed the presence of peptides and glycoprotein molecules, with an increase in the distribution of larger peptide size chains. The conjugated SPIH-YCE (10 days) exhibited the highest antioxidant capacity compared to the other samples at different incubation times. A comparative study between SPIH-YCE (day 0) and SPIH-YCE after 10 days of incubation showed significantly higher anti-inflammatory and ACE inhibitory activities for the conjugates subjected to the humid-dry heating process. This suggests that SPIH-YCE conjugates could serve as an alternative substance with the potential to provide health benefits by mitigating or preventing non-communicable diseases (NCDs). This research highlights the importance of the Maillard reaction in enhancing bioactivity and offers insights into the alterations of the chemical structure of these conjugates.

Indexed as

angiotensin I-converting enzyme (ACE) inhibitory activityanti-inflammatory activityantioxidant activityhumid–dry heatingMaillard reactionsoyyeast

Identifiers

PMID38338515
PMCPMC10855142
OpenAlexW4391175360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.