ReviewPharmaceuticals (Basel, Switzerland)2024
A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest.
Review in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 165 citations in OpenAlex.
- Advanced hydrogel-based drug delivery systems for psoriasis management: From material design to multi-target therapies.International journal of pharmaceutics: X · 2026Review
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- Deep Eutectic Solvents for Ammonia Capture and Detection: Molecular Design, Absorption Mechanisms, and Analytical Applications: A Brief Review.International journal of molecular sciences · 2026Review
- Natural Deep Eutectic Solvent-Based Extraction of Flavonoids fromMolecules (Basel, Switzerland) · 2026Article
- Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- New Parametric Model for Estimating the Viscosity of Choline Chloride-Based Deep Eutectic Solvents and Their Aqueous Mixtures.Molecules (Basel, Switzerland) · 2026Article
- Valorization of Olive Pomace as a Source of Phenolic Compounds: Extraction Technologies, Analytical Characterization, Biological Activities, and Food Applications.Foods (Basel, Switzerland) · 2026Review
- From Solvent Design to Biological Response: Structure-Property Relationships of Edible Natural Deep Eutectic Solvents for the Extraction ofMolecules (Basel, Switzerland) · 2026Article
- From Oilseed Waste to High-Value Bioactives: Deep Eutectic Solvents as Sustainable Refining Media.International journal of molecular sciences · 2026Review
- Eco-Friendly Amide Synthesis Using a Metal and Halogen-Free Deep Eutectic Solvent.Chemistry, an Asian journal · 2026Article
- From static compromise to dynamic design: a polarity modulation paradigm for multiclass veterinary drug residue analysis in complex foods.Food chemistry: X · 2026Review
- Deep Eutectic Solvent-Assisted Synergistic Technologies for the Extraction of Natural Bioactive Compounds: Enhancement Mechanisms, Application Advances, and Challenges.Foods (Basel, Switzerland) · 2026Review
- Mechanochemical Synthesis of Valproic Acid-Based Hybrids: Antioxidant, Anti-Inflammatory, and In Silico Evaluation.Molecules (Basel, Switzerland) · 2026Article
- Red Seaweed-Derived Phycobiliproteins: Marine Bioactive Colorants with Functional Health Properties.Marine drugs · 2026Review
- Bridging in vitro bioactivities and in silico insights of Rubia cordifolia L. (Rubiaceae) leaf extracts for therapeutic applications.Scientific reports · 2026Article
- Enhanced extraction and functional properties of 3-deoxyanthocyanidins from red sorghum leaf sheaths via ultrasound-assisted extraction with natural deep eutectic solvent.Ultrasonics sonochemistry · 2026Article
- Ursolic Acid-fatty Acid Based Therapeutic Deep Eutectic Solvents: Response Surface Methodology Based Optimization and in vivo anti-microbial Effects against MRSA.Cell biochemistry and biophysics · 2026Article
- Shelf life and time-resolved thermal, chemical, and thermodynamic characterization of four hydrophobic deep eutectic solvents.RSC advances · 2026Article
- Crustacean and Mollusc Shell Proteins: Origin, Structure, and Functionality.Journal of food science · 2026Review
- Deep Eutectic Solvents for Sustainable Extraction of Bioactive Compounds from Biomass: Mechanistic Insights and Scale-Up Challenges.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The extraction of bioactive compounds of pharmaceutical interest from natural sources has been significantly explored in recent decades. However, the extraction techniques used were not very efficient in terms of time and energy consumption; additionally, the solvents used for the extraction were harmful for the environment. To improve the environmental impact of the extractions and at the same time increase the extraction yields, several new extraction techniques were developed. Among the most used ones are ultrasound-assisted extraction and microwave-assisted extraction. These extraction techniques increased the yield and selectivity of the extraction in a smaller amount of time with a decrease in energy consumption. Nevertheless, a high volume of organic solvents was still used for the extraction, causing a subsequent environmental problem. Neoteric solvents appeared as green alternatives to organic solvents. Among the neoteric solvents, deep eutectic solvents were evidenced to be one of the best alternatives to organic solvents due to their intrinsic characteristics. These solvents are considered green solvents because they are made up of natural compounds such as sugars, amino acids, and carboxylic acids having low toxicity and high degradability. In addition, they are simple to prepare, with an atomic economy of 100%, with attractive physicochemical properties. Furthermore, the huge number of compounds that can be used to synthesize these solvents make them very useful in the extraction of bioactive compounds since they can be tailored to be selective towards a specific component or class of components. The main aim of this paper is to give a comprehensive review which describes the main properties, characteristics, and production methods of deep eutectic solvents as well as its application to extract from natural sources bioactive compounds with pharmaceutical interest. Additionally, an overview of the more recent and sustainable extraction techniques is also given.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.