Evidence map›Paper›PMID 37998810›Full record

ReviewAntibiotics (Basel, Switzerland)2023

Mechanisms and Applications of Citral's Antimicrobial Properties in Food Preservation and Pharmaceuticals Formulations.

María Melissa Gutiérrez-Pacheco, Heriberto Torres-Moreno, María Liliana Flores-Lopez, Norma Velázquez Guadarrama, J Fernando Ayala-Zavala, Luis Alberto Ortega-Ramírez, Julio César López-Romero

Abstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  13. Unraveling the Effects ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

María Melissa Gutiérrez-PachecoDepartamento de Ciencias de la Salud, Universidad Estatal de Sonora, San Luis Río Colorado 83430, Sonora, Mexico.
Heriberto Torres-MorenoDepartamento de Ciencias Químico-Biológicas y Agropecuarias, Universidad de Sonora, H. Caborca 83600, Sonora, Mexico.ORCID 0000-0002-3102-8642
María Liliana Flores-LopezCentro de Investigación e Innovación Científica y Tecnológica, Universidad Autónoma de Coahuila, Saltillo 25070, Coahuila, Mexico.ORCID 0000-0002-9405-4848
Norma Velázquez GuadarramaLaboratorio de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.ORCID 0000-0002-3620-7260
J Fernando Ayala-ZavalaCoordinación de Tecnología de Alimentos de Origen Vegetal, Centro de Investigación en Alimentación y Desarrollo, A. C. Carretera Gustavo Astiazarán Rosas No. 46, Colonia la Victoria, Hermosillo 83304, Sonora, Mexico.ORCID 0000-0002-0691-6453
Luis Alberto Ortega-RamírezDepartamento de Ciencias de la Salud, Universidad Estatal de Sonora, San Luis Río Colorado 83430, Sonora, Mexico.
Julio César López-RomeroDepartamento de Ciencias Químico-Biológicas y Agropecuarias, Universidad de Sonora, H. Caborca 83600, Sonora, Mexico.ORCID 0000-0002-5662-175X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Citral is a monoterpene constituted by two isomers known as neral and geranial. It is present in different plant sources and recognized as safe (GRAS) by the Food and Drug Administration (FDA). In recent years, investigations have demonstrated that this compound exhibited several biological activities, such as antibacterial, antifungal, antibiofilm, antiparasitic, antiproliferative, anti-inflammatory, and antioxidant properties, by in vitro and in vivo assays. Additionally, when incorporated into different food matrices, citral can reduce the microbial load of pathogenic microorganisms and extend the shelf life. This compound has acceptable drug-likeness properties and does not present any violations of Lipinski's rules, which could be used for drug development. The above shows that citral could be a compound of interest for developing food additives to extend the shelf life of animal and vegetable origin foods and develop pharmaceutical products.

Indexed as

biological activitiescitralfood additivepharmaceuticals

Identifiers

PMID37998810
PMCPMC10668791

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.