Evidence map›Paper›PMID 37730162›Full record

ArticleJournal of lipid research2023

Lipidomic studies reveal two specific circulating phosphatidylcholines as surrogate biomarkers of the omega-3 index.

Ritchie Ly, Brittany C MacIntyre, Stuart M Philips, Chris McGlory, David M Mutch, Philip Britz-McKibbin

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07004777 (Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein Composition in Individuals With Hypertriglyceridemia. Controlled Clinical Trial.), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07004777 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein Composition in Individuals With Hypertriglyceridemia. Controlled Clinical Trial.

TypeinterventionalSponsorInstituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranRan2026 to 2027Enrolled375ConditionsHypertriglyceridemiaArmsIsocaloric diet including chia and pumpkin seeds, Isocaloric diet
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ritchie LyDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Brittany C MacIntyreDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Stuart M PhilipsDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Chris McGloryDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada; School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
David M MutchDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Philip Britz-McKibbinDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada. Electronic address: britz@mcmaster.ca.
McMaster University · CAUniversity of Guelph · CAQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optimal dietary intake of omega-3 long-chain polyunsaturated fatty acids (n3-LCPUFAs) is critical to human health across the lifespan. However, omega-3 index (O3I) determination is not routinely assessed due to complicated procedures for n3-LCPUFA analysis from the phospholipid (PL) fraction of erythrocytes. Herein, a high-throughput method for lipidomics based on multisegment injection-nonaqueous capillary electrophoresis-mass spectrometry was applied to identify circulating PLs as surrogate biomarkers of O3I in two randomized placebo-controlled trials. An untargeted lipidomic data workflow using a subgroup analysis of serum extracts from sunflower oil versus high-dose fish oil (FO)-supplemented participants revealed that ingested n3-LCPUFAs were primarily distributed as their phosphatidylcholines (PCs) relative to other PL classes. In both high-dose FO (5.0 g/day) and EPA-only trials (3.0 g/day), PC (16:0_20:5) was the most responsive PL, whereas PC (16:0_22:6) was selective to DHA-only supplementation. We also demonstrated that the sum concentration of both these PCs in fasting serum or plasma samples was positively correlated to the O3I following FO (r = 0.708, P = 1.02 × 10

Indexed as

Fatty Acids, Omega-3LipidomicsAdultBiomarkersCanadaDietary SupplementsDocosahexaenoic AcidsEicosapentaenoic AcidFish OilsHumansPhosphatidylcholinesBiomarkersDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Fish OilsPhosphatidylcholinesBiomarkersBloodFish oilLipidomicsNutritionOmega-3-indexOmega-3 long-chain polyunsaturated fatty acidsPhosphatidylcholinesSupplementation

Identifiers

PMID37730162
PMCPMC10622695
OpenAlexW4386840907

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.