ArticleFoods (Basel, Switzerland)2023
Improved Loading Capacity and Viability of Probiotics Encapsulated in Alginate Hydrogel Beads by In Situ Cultivation Method.
Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review
- Enhanced Storage Stability and Gastrointestinal Survival of Lactiplantibacillus plantarum by Sodium Alginate-Resistant Starch-EGCG Composite Encapsulation.Journal of food science · 2026Article
- Development and Functional Evaluation of a Pharmabiotic Food Supplement Containing MicroencapsulatedFood science & nutrition · 2026Article
- Alginate-Based Encapsulation ofFood science & nutrition · 2026Article
- Development of Sodium Alginate/Cellulose Nanofiber (SA/CNF)-Based Hydrogels for Enhancing Probiotic Stability.Gels (Basel, Switzerland) · 2026Article
- pH-TriggeredRelease of Cinnamon Essential Oil from Sodium Alginate-Shellac Nanoparticles: Rational Design, Enhanced Stability and Antibacterial Efficacy.Foods (Basel, Switzerland) · 2026Article
- Hydrogel platforms for engineered live biotherapeutics: materials, microbial integration and clinical potential.RSC pharmaceutics · 2026Review
- The Incorporation of Plant-Derived Polysaccharides into Alginate-Based Capsules Improve Probiotic Viabilities During Storage, Gastrointestinal Digestion, and Their Application in Yogurt.Foods (Basel, Switzerland) · 2026Article
- Hydrogel-based experimental models of the gastrointestinal tract.Microbiome · 2025Review
- Date yogurt supplemented withFood science & nutrition · 2024Article
- Composite alginate-based hydrogel delivery of antioxidant pumpkin protein hydrolysate in simulated gastrointestinal condition.Current research in food science · 2024Article
- Protective Effect of Alginate Microcapsules with Different Rheological Behavior onGels (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The objective of this research was to encapsulate probiotics by alginate hydrogel beads based on an in situ cultivation method and investigate the influences on the cell loading capacity, surface and internal structure of hydrogel beads and in vitro gastrointestinal digestion property of cells. Hydrogel beads were prepared by extrusion and cultured in MRS broth to allow probiotics to grow inside. Up to 10.34 ± 0.02 Log CFU/g of viable cell concentration was obtained after 24 h of in situ cultivation, which broke through the bottleneck of low viable cell counts in the traditional extrusion method. Morphology and rheological analyses showed that the structure of the eventually formed probiotic hydrogel beads can be loosed by the existence of hydrogen bond interaction with water molecules and the internal growth of probiotic microcolonies, while it can be tightened by the acids metabolized by the probiotic bacteria during cultivation. In vitro gastrointestinal digestion analysis showed that great improvement with only 1.09 Log CFU/g of loss in viable cells was found after the entire 6 h of digestion. In conclusion, the current study demonstrated that probiotic microcapsules fabricated by in situ cultivation method have the advantages of both high loading capacity of encapsulated viable cells and good protection during gastrointestinal digestion.
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