Evidence map›Paper›PMID 37234631›Full record

ReviewHeliyon2023

Gelatin nanofibers: Recent insights in synthesis, bio-medical applications and limitations.

Hesham R El-Seedi, Noha S Said, Nermeen Yosri, Hamada B Hawash, Dina M El-Sherif, Mohamed Abouzid, Mohamed M Abdel-Daim, Mohammed Yaseen, Hany Omar, Qiyang Shou and 4 more

Abstract readReview
In one paragraph

Review in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hesham R El-SeediInternational Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China.
Noha S SaidDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt.
Nermeen YosriChemistry Department of Medicinal and Aromatic Plants, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef 62514, Egypt.
Hamada B HawashEnvironmental Division, National Institute of Oceanography and Fisheries, NIOF, Cairo, Egypt.
Dina M El-SherifNational Institute of Oceanography and Fisheries, NIOF, Cairo, Egypt.
Mohamed AbouzidDepartment of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
Mohamed M Abdel-DaimDepartment of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231 Jeddah 21442, Saudi Arabia.
Mohammed YaseenSchool of Computing, Engineering & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK.
Hany OmarResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
Qiyang ShouSecond Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Nour F AttiaGas Analysis and Fire Safety Laboratory, Chemistry Division, National Institute of Standards, 136, Giza 12211, Egypt.
Xiaobo ZouSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
Zhiming GuoSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
Shaden A M KhalifaPsychiatry and Psychology Department, Capio Saint Göran's Hospital, Sankt Göransplan 1, 112 19 Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of gelatin and gelatin-blend polymers as environmentally safe polymers to synthesis electrospun nanofibers, has caused a revolution in the biomedical field. The development of efficient nanofibers has played a significant role in drug delivery, and for use in advanced scaffolds in regenerative medicine. Gelatin is an exceptional biopolymer, which is highly versatile, despite variations in the processing technology. The electrospinning process is an efficient technique for the manufacture of gelatin electrospun nanofibers (GNFs), as it is simple, efficient, and cost-effective. GNFs have higher porosity with large surface area and biocompatibility, despite that there are some drawbacks. These drawbacks include rapid degradation, poor mechanical strength, and complete dissolution, which limits the use of gelatin electrospun nanofibers in this form for biomedicine. Thus, these fibers need to be cross-linked, in order to control its solubility. This modification caused an improvement in the biological properties of GNFs, which made them suitable candidates for various biomedical applications, such as wound healing, drug delivery, bone regeneration, tubular scaffolding, skin, nerve, kidney, and cardiac tissue engineering. In this review an outline of electrospinning is shown with critical summary of literature evaluated with respect to the various applications of nanofibers-derived gelatin.

Indexed as

ElectrospinningGelatinMedical applicationNanofibersTissue engineering

Identifiers

PMID37234631
PMCPMC10205520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.