Evidence map›Paper›PMID 36872576›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2023

Does preschool executive control mediate the impact of early environmental unpredictability and deprivation on the general factor of psychopathology a decade later?

Eric M Phillips, Rebecca L Brock, Tiffany D James, Jennifer Mize Nelson, W Alex Mason, Kimberly Andrews Espy, Timothy D Nelson

Abstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Eric M PhillipsDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID 0000-0002-9498-2249
Rebecca L BrockDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Tiffany D JamesOffice of Research and Economic Development, University of Nebraska-Lincoln, Lincoln, NE, USA.
Jennifer Mize NelsonDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
W Alex MasonDepartment of Child, Youth, & Family Studies, Nebraska Center for Research on Children, Youth, Families, and Schools, University of Nebraska-Lincoln, Lincoln, NE, USA.
Kimberly Andrews EspyDepartment of Neuroscience, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA.
Timothy D NelsonDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.

Funding

Testing the Efficacy of Ibudilast to Attenuate Meth-seeking and Associated Synaptic Inflammation at the Synapse (TEAMS)P20GM130461 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI KIMBERLY A TYLER · 2019 to 2026
$20.6M
Executive Function Development in Preschool ChildrenR01MH065668 · NIMH · UNIVERSITY OF NEBRASKA LINCOLN · PI ESPY, KIMBERLY ANDREWS, WIEBE, SANDRA A. · 2004 to 2013
$4.8M
Neural Vulnerabilities for Obesity: A Contextualized, Longitudinal Study in AdolescenceR01DK116693 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI Timothy David Nelson, Maital Neta · 2018 to 2026
$4.0M
Role of Executive Control in Adolescent Substance Use and Co-occuring ProblemsR01DA041738 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MASON, W ALEX, NELSON, TIMOTHY DAVID · 2017 to 2021
$3.1M
Modifiable predictors of neural vulnerabilities for obesityR01DK125651 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI NELSON, TIMOTHY DAVID, SAVAGE, CARY R · 2020 to 2024
$3.0M
NIDA NIH HHS R01 DA041738NIDA NIH HHS R01DA041738NIDDK NIH HHS R01 DK116693NIDDK NIH HHS R01DK116693NIDDK NIH HHS R01 DK125651NIDDK NIH HHS R01DK125651NIGMS NIH HHS P20 GM130461NIGMS NIH HHS P20GM130461NIMH NIH HHS R01 MH065668NIMH NIH HHS R01MH065668
6 · The paper itself

Abstract

backgroundAlthough deprivation has been consistently shown to increase risk for psychopathology through impaired executive control, the unique effects of other dimensions of early adversity, such as unpredictability, on executive control development are poorly understood. The current study evaluated whether deprivation and/or unpredictability early in life have unique effects on the general factor of psychopathology through impaired preschool executive control.

methodsParticipants included 312 children (51% female) oversampled for greater sociodemographic risk. Preschool executive control was measured using a battery of nine developmentally appropriate executive control tasks. Dimensions of adversity were measured with observational and caregiver assessments, and psychopathology was measured with caregiver and child reports.

resultsIn separate models, both deprivation and unpredictability had significant indirect effects on the adolescent general factor of psychopathology through impaired preschool executive control. However, when both dimensions of adversity were included simultaneously, early life deprivation, but not unpredictability, was uniquely associated with the general factor of psychopathology in adolescence through impaired preschool executive control.

conclusionsPreschool executive control appears to be a transdiagnostic mechanism through which deprivation, but not unpredictability, increases risk for the general factor of psychopathology in adolescence. Results elucidate potential transdiagnostic targets for intervention efforts aimed at reducing the development and maintenance of psychopathology across the life span.

Indexed as

Executive FunctionMental DisordersAdolescentChildChild, PreschoolFemaleHumansMalePsychopathologySchoolsadversityDeprivationexecutive controlgeneral factor of psychopathologytransdiagnosticunpredictability

Identifiers

PMID36872576
PMCPMC10911046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.