Evidence map›Paper›PMID 36823295›Full record

ArticleScientific reports2023

Enhanced bone tissue regeneration using a 3D-printed poly(lactic acid)/Ti6Al4V composite scaffold with plasma treatment modification.

Masoud Zarei, Motahareh Shabani Dargah, Mahdi Hasanzadeh Azar, Reza Alizadeh, Fatemeh Sadat Mahdavi, Sayed Shahab Sayedain, Alireza Kaviani, Mohammad Asadollahi, Mahmoud Azami, Nima Beheshtizadeh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Masoud ZareiDepartment of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran. m.zarei72@sharif.edu.
Motahareh Shabani Dargah *Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
Mahdi Hasanzadeh Azar *Department of Engineering Physics, McMaster University, Hamilton, Canada.
Reza AlizadehDepartment of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran. r.alizadeh@sharif.edu.
Fatemeh Sadat MahdaviDepartment of Biotechnology Engineering, College of Science, University of Tehran, Tehran, Iran.
Sayed Shahab SayedainDepartment of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.
Alireza KavianiPolymeric Materials Research Group (PMRG), Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.
Mohammad AsadollahiDepartment of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.
Mahmoud AzamiDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nima BeheshtizadehDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. n-beheshtizadeh@razi.tums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanical and biological properties of polylactic acid (PLA) need to be further improved in order to be used for bone tissue engineering (BTE). Utilizing a material extrusion technique, three-dimensional (3D) PLA-Ti6Al4V (Ti64) scaffolds with open pores and interconnected channels were successfully fabricated. In spite of the fact that the glass transition temperature of PLA increased with the addition of Ti64, the melting and crystallization temperatures as well as the thermal stability of filaments decreased slightly. However, the addition of 3-6 wt% Ti64 enhanced the mechanical properties of PLA, increasing the ultimate compressive strength and compressive modulus of PLA-3Ti64 to 49.9 MPa and 1.9 GPa, respectively. Additionally, the flowability evaluations revealed that all composite filaments met the print requirements. During the plasma treatment of scaffolds, not only was the root-mean-square (Rq) of PLA (1.8 nm) increased to 60 nm, but also its contact angle (90.4°) significantly decreased to (46.9°). FTIR analysis confirmed the higher hydrophilicity as oxygen-containing groups became more intense. By virtue of the outstanding role of plasma treatment as well as Ti64 addition, a marked improvement was observed in Wharton's jelly mesenchymal stem cell attachment, proliferation (4',6-diamidino-2-phenylindole staining), and differentiation (Alkaline phosphatase and Alizarin Red S staining). Based on these results, it appears that the fabricated scaffolds have potential applications in BTE.

Indexed as

Printing, Three-DimensionalTissue ScaffoldsAlloysBone RegenerationPolyestersTissue EngineeringTitaniumAlloysPolyesterspoly(lactide)Titaniumtitanium alloy (TiAl6V4)

Identifiers

PMID36823295
PMCPMC9950435

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.