Evidence map›Paper›PMID 36770780›Full record

ReviewMolecules (Basel, Switzerland)2023

Future Antimicrobials: Natural and Functionalized Phenolics.

Andrei Lobiuc, Naomi-Eunicia Pavăl, Ionel I Mangalagiu, Roxana Gheorghiță, Gabriel-Ciprian Teliban, Dorina Amăriucăi-Mantu, Vasile Stoleru

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Antibacterial characteristics of black currant fruit extracts.BMC complementary medicine and therapies · 2026
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  12. Phytochemicals fromFoods (Basel, Switzerland) · 2026
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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrei LobiucFaculty of Medicine and Biological Sciences, "Ştefan cel Mare" University, 720229 Suceava, Romania.
Naomi-Eunicia PavălFaculty of Medicine and Biological Sciences, "Ştefan cel Mare" University, 720229 Suceava, Romania.
Ionel I MangalagiuFaculty of Chemistry, "Alexandru Ioan Cuza" University, 700506 Iasi, Romania.ORCID 0000-0002-4632-5076
Roxana GheorghițăFaculty of Medicine and Biological Sciences, "Ştefan cel Mare" University, 720229 Suceava, Romania.
Gabriel-Ciprian TelibanDepartment of Horticulture Technologies, "Ion Ionescu de la Brad" University of Life Sciences, 700490 Iasi, Romania.
Dorina Amăriucăi-MantuFaculty of Chemistry, "Alexandru Ioan Cuza" University, 700506 Iasi, Romania.
Vasile StoleruDepartment of Horticulture Technologies, "Ion Ionescu de la Brad" University of Life Sciences, 700490 Iasi, Romania.ORCID 0000-0003-0485-0312

Funding

Ministry of Research, Innovation and Digitization, CCCDI-UEFISCDI PN-III-P2-2.1-PED-2021-4380
6 · The paper itself

Abstract

With incidence of antimicrobial resistance rising globally, there is a continuous need for development of new antimicrobial molecules. Phenolic compounds having a versatile scaffold that allows for a broad range of chemical additions; they also exhibit potent antimicrobial activities which can be enhanced significantly through functionalization. Synthetic routes such as esterification, phosphorylation, hydroxylation or enzymatic conjugation may increase the antimicrobial activity of compounds and reduce minimal concentrations needed. With potent action mechanisms interfering with bacterial cell wall synthesis, DNA replication or enzyme production, phenolics can target multiple sites in bacteria, leading to a much higher sensitivity of cells towards these natural compounds. The current review summarizes some of the most important knowledge on functionalization of natural phenolic compounds and the effects on their antimicrobial activity.

Indexed as

Anti-Infective AgentsAnti-Bacterial AgentsAntioxidantsPhenolsPlant ExtractsAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsPhenolsPlant Extractsalkylationesterificationflavonoidslignansminimal inhibitory concentrationtannins

Identifiers

PMID36770780
PMCPMC9920704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.