Evidence map›Paper›PMID 36682497›Full record

ArticleThe Journal of biological chemistry2023

Influence of glycoprotein MUC1 on trafficking of the Ca

Mohammad M Al-Bataineh, Carol L Kinlough, Allison Marciszyn, Tracey Lam, Lorena Ye, Kendrah Kidd, Joseph C Maggiore, Paul A Poland, Stanislav Kmoch, Anthony Bleyer and 5 more

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Expression and distribution of MUC1 in the developing and adult kidney.American journal of physiology. Renal physiology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Mohammad M Al-BatainehRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Carol L KinloughRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Allison MarciszynRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Tracey LamRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lorena YeRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kendrah KiddSection on Nephrology, Department of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA; Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Joseph C MaggioreDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Paul A PolandRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Stanislav KmochSection on Nephrology, Department of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA; Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Anthony BleyerSection on Nephrology, Department of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA; Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Daniel J BainDepartment of Geology and Environmental Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nicolas MontalbettiRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thomas R KleymanRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rebecca P HugheyRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: hugheyr@pitt.edu.
Evan C RayRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USCharles University · CZ

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Regulation of K and H secretion by intercalated cellsR01DK038470 · NIDDK · YESHIVA UNIVERSITY · PI HUGHEY, REBECCA P, KLEYMAN, THOMAS R · 1994 to 2022
$7.7M
Renal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1M
Proteolytic activation of ENaC in Proteinuric Kidney DiseaseK08DK110332 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, EVAN CROSS · 2016 to 2021
$903k
Role of Muc1 in the b-catenin Response to Acute Kidney InjuryK01DK109038 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AL-BATAINEH, MOHAMMAD · 2016 to 2021
$798k
Role of the MUC1/HIF-1a Complex in the kidney proximal tubule during ischemia-reperfusion injury.R03DK131093 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AL-BATAINEH, MOHAMMAD · 2022 to 2023
$236k
NIDDK NIH HHS K01 DK109038NIDDK NIH HHS K08 DK110332NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK038470NIDDK NIH HHS R03 DK131093NIDDK NIH HHS T32 DK061296
6 · The paper itself

Abstract

Polymorphism of the gene encoding mucin 1 (MUC1) is associated with skeletal and dental phenotypes in human genomic studies. Animals lacking MUC1 exhibit mild reduction in bone density. These phenotypes could be a consequence of modulation of bodily Ca homeostasis by MUC1, as suggested by the previous observation that MUC1 enhances cell surface expression of the Ca

Indexed as

CalciumMucin-1TRPV Cation ChannelsAnimalsCalcium ChannelsCell MembraneCells, CulturedEpithelial CellsFemaleHumansMaleMiceMutationProtein TransportSex FactorsCalciumCalcium ChannelsMUC1 protein, humanMucin-1Trpv5 protein, mouseTrpv6 protein, mouseTRPV Cation ChannelsCa homeostasisMUC1mucin 1TRPV5TRPV6

Identifiers

PMID36682497
PMCPMC9996365
OpenAlexW4317521345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.