ArticleMicroorganisms2022
Effect of Trehalose and Lactose Treatments on the Freeze-Drying Resistance of Lactic Acid Bacteria in High-Density Culture.
Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Thermo-Responsive Living Microspheroids Enable a Regenerative Living Disk-Drive System for DNA Data Storage.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Optimizing 3D-printed core-shell hydrogel system for probiotic protection: stability under in vitro digestion conditions and during storage.Journal of biological engineering · 2026Article
- Potent Probiotic YeastACS omega · 2026Article
- Skim Milk as a Multifunctional Cryoprotectant for Fish ProbioticMicroorganisms · 2025Article
- Overview of Glycometabolism of Lactic Acid Bacteria During Freeze-Drying: Changes, Influencing Factors, and Application Strategies.Foods (Basel, Switzerland) · 2025Review
- Development and Characterization of Lyophilized Chondroitin Sulfate-Loaded Solid Lipid Nanoparticles: Encapsulation Efficiency and Stability.Pharmaceutics · 2025Article
- Trehalose and maltodextrin preserve microbial community structure in freeze-dried fecal samples for fecal microbiota transplantation.ISME communications · 2025Article
- Development of a fermented quinoa beverage with autochthonous lactic acid bacteria.Frontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Freeze-drying is a commonly used method in commercial preparations of lactic acid bacteria. However, some bacteria are killed during the freeze-drying process. To overcome this, trehalose and lactose are often used as protective agents. Moreover, high-density culture is an efficient way to grow bacterial strains but creates a hypertonic growth environment. We evaluated the effects of trehalose and lactose, as a primary carbon source or as an additive in fermentation, on the freeze-drying survival of
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Registered trials
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