ArticleAerosol science and technology : the journal of the American Association for Aerosol Research2019
Toxic emissions resulting from sucralose added to electronic cigarette liquids.
Article in Aerosol science and technology : the journal of the American Association for Aerosol Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Flavor-Toxicant Correlation in E-cigarettes: A Meta-Analysis.Chemical research in toxicology · 2020Pooled it
- Aerosol, vapor, or chemicals? College student perceptions of harm from electronic cigarettes and support for a tobacco-free campus policy.Journal of American college health : J of ACHTrial
- Chemosensory tobacco product toxicology part 2: toxicological testing, assays, and state of the science.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Review
- Sugars in Tobacco Products: Toxicity Research and Implications for Tobacco Product Regulation.Chemical research in toxicology · 2025Review
- Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to 2- and 3-monochloropropanediol (urinary excretion) and glycidol (hemoglobin adduct N-2,3-dihydroxypropyl-Val).Archives of toxicology · 2025Article
- A Review of the Toxicity of Ingredients in e-Cigarettes, Including Those Ingredients Having the FDA's "Generally Recognized as Safe (GRAS)" Regulatory Status for Use in Food.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Review
- Assessment of human abuse potential of an unflavored, sucralose-sweetened electronic cigarette in combustible cigarette smokers.Experimental and clinical psychopharmacology · 2024Article
- The impact of sucralose and neotame on the safety of metal precipitation in electronic cigarettes.Frontiers in physiology · 2024Article
- Secondhand electronic cigarette aerosol in vehicles impacts indoor air quality.Drug and alcohol dependence · 2023Article
- Quantitation of Flavor Compounds in Refill Solutions for Electronic Cigarettes Using HS-GCxIMS and Internal Standards.Molecules (Basel, Switzerland) · 2022Article
- Assessing toxicant emissions from e-liquids with DIY additives used in response to a potential flavour ban in e-cigarettes.Tobacco control · 2022Article
- Laboratory Determination of Gravimetric Correction Factors for Real-time Area Measurements of Electronic Cigarette Aerosols.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2022Article
- 9. Flavours in novel and emerging nicotine and tobacco products.World Health Organization technical report series · 2021Article
- Electronic Cigarettes Are Chemical Reactors: Implication to Toxicity.Chemical research in toxicology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Electronic cigarettes (ECIGs) are appealing in part because of the many flavors of the liquids used in them. Concerns have been raised that some ECIG liquid flavors, especially those that are sweet, are attracting otherwise nicotine-naïve youth to ECIGs. Sucralose is an artificial, non-caloric sweetener that is added to some ECIG liquids. In this study, we evaluated the toxicants, namely isomers of chloropropanols that can be produced when sucralose-containing ECIG liquid is aerosolized. An analytical separation method relying on solid-phase extraction (SPE) to isolate chloropropanols from the propylene glycol/glycerol matrix was developed. Chloropropanols were then derivatized by silylation before they were analyzed on GC-MS. The influence of different ECIG operating conditions on the generation of chloropropanols was studied by varying ECIG device design and power output and also the sucralose concentration of the liquid. Heated sucralose-containing ECIG liquids produce two toxic compounds that can be found in the resulting aerosols. The two chloropropanols, 3-monochloro-1,2-propanediol (3-MCPD) and 1,3-dichloropropanol (1,3-DCP) that were detected under all conditions were found to be correlated significantly with liquid sucralose content. Effective regulation of ECIGs will minimize user and bystander exposure to these and other ECIG toxicants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.