Evidence map›Paper›PMID 35938460›Full record

ReviewCurrent opinion in HIV and AIDS2022

Cardiovascular disease risk in women living with HIV.

Katherine Kentoffio, Tecla M Temu, Saate S Shakil, Markella V Zanni, Chris T Longenecker

Abstract readReview
In one paragraph

Review in Current opinion in HIV and AIDS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Pitavastatin to Prevent Cardiovascular Disease in HIV Infection.The New England journal of medicine · 2023 · on this map
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katherine KentoffioDivision of Cardiology, Department of Medicine, University of California, San Francisco, California.
Tecla M TemuDepartment of Global Health, University of Washington School of Medicine.
Saate S ShakilDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington.
Markella V ZanniDivision of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Chris T LongeneckerDepartment of Global Health, University of Washington School of Medicine.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
CARDIOVASCULAR RESEARCH TRAINING PROGRAMT32HL007828 · NHLBI · UNIVERSITY OF WASHINGTON · PI Francis Kim, Farid Moussavi-Harami · 1997 to 2026
$10.2M
Arterial Inflammation and Coronary Microvascular Dysfunction among Women with HIV: Missing Pieces to the MI Risk PuzzleR01HL146267 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ZANNI, MARKELLA V. · 2019 to 2022
$3.4M
Consequences of Persistent Immune Activation among ART-treated Women with HIVK24AI157882 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ZANNI, MARKELLA V. · 2021 to 2025
$908k
Pericardial fat, inflammation, and structural heart disease in HIVK23HL123341 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI LONGENECKER, CHRIS TODD · 2014 to 2018
$885k
The Gut Microbiota, Inflammation and Cardiovascular Disease in HIV-InfectedIndividuals.K01HL147723 · NHLBI · UNIVERSITY OF WASHINGTON · PI TEMU, TECLA MTUI · 2020 to 2022
$505k
NHLBI NIH HHS K01 HL147723NHLBI NIH HHS K23 HL123341NHLBI NIH HHS R01 HL146267NHLBI NIH HHS T32 HL007828NIAID NIH HHS K24 AI157882NIAID NIH HHS P30 AI027757
6 · The paper itself

Abstract

purpose of reviewTo synthesize current evidence on the impact of cardiovascular disease among women living with HIV (WLWH) with a particular focus on disease prevalence, mechanisms and prevention. RECENT

findingsHIV-related cardiovascular disease risk is 1.5-fold to 2-fold higher for women than for men. Mechanisms of enhanced risk are multifactorial and include reinforcing pathways between traditional risk factors, metabolic dysregulation, early reproductive aging and chronic immune activation. These pathways influence both the presentation of overt syndromes of myocardial infarction, stroke and heart failure, as well as subclinical disease, such as microvascular dysfunction and cardiac fibrosis. Cardiovascular disease, therefore, remains a consistent threat to healthy aging among WLWH. SUMMARY: Although no specific prevention strategies exist, patient-centered risk mitigation approaches that are adaptable to the needs of aging individuals are essential to combat disparities in cardiovascular outcomes among WLWH. Further research into the optimal prevention approach for CVD among WLWH, particularly for women living in under-resourced health systems, is needed.

Indexed as

Cardiovascular DiseasesHIV InfectionsMyocardial InfarctionFemaleHumansMalePrevalenceRisk Factors

Identifiers

PMID35938460
PMCPMC9370828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.