Evidence map›Paper›PMID 35859879›Full record

ArticleACS medicinal chemistry letters2022

Novel Isoindolinone-Based Analogs of the Natural Cyclic Peptide Fenestin A: Synthesis and Antitumor Activity.

Huanli Zhang, Jingwan Wu, Jingchun Wang, Shimei Xiao, Lei Zhao, Rui Yan, Xiaodan Wu, Zhiqiang Wang, Li Fan, Yingxue Jin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. CFNature communications · 2025
    Article
  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Huanli ZhangKey Laboratory for Photonic and Electronic Bandgap Materials (Ministry of Education), College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.
Jingwan WuKey Laboratory for Photonic and Electronic Bandgap Materials (Ministry of Education), College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.
Jingchun WangKey Laboratory for Photonic and Electronic Bandgap Materials (Ministry of Education), College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.
Shimei XiaoKey Laboratory for Photonic and Electronic Bandgap Materials (Ministry of Education), College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.
Lei ZhaoKey Laboratory for Photonic and Electronic Bandgap Materials (Ministry of Education), College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.
Rui YanKey Laboratory for Photonic and Electronic Bandgap Materials (Ministry of Education), College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.
Xiaodan WuKey Laboratory for Photonic and Electronic Bandgap Materials (Ministry of Education), College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.
Zhiqiang WangKey Laboratory for Photonic and Electronic Bandgap Materials (Ministry of Education), College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.ORCID https://orcid.org/0000-0002-5573-455X
Li FanInstitute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar 161006, P. R. China.
Yingxue JinKey Laboratory for Photonic and Electronic Bandgap Materials (Ministry of Education), College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.ORCID https://orcid.org/0000-0001-7976-2785
Harbin Normal University · CNQiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small- and medium-sized cyclopeptides have been found to have extensive bioactivities and have drawn much attention from medicinal chemists. In the work described in this paper, various cyclic peptide analogs of Fenestin A were synthesized by intramolecular photoinduced electron-transfer cyclization reactions to study the influence of slight structural changes on the bioactivity of small cyclopeptides. The incorporation of thiazole and rigid isoindolinone fragments was found to improve the bioactivity of the cyclopeptide. Detailed

Identifiers

PMID35859879
PMCPMC9290000
OpenAlexW4286591672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.