Evidence map›Paper›PMID 35745772›Full record

ArticlePharmaceutics2022

WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy.

Valentina O Plastun, Ekaterina S Prikhozhdenko, Olga I Gusliakova, Svetlana V Raikova, Timothy E L Douglas, Olga A Sindeeva, Oksana A Mayorova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Valentina O PlastunScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0002-6235-490X
Ekaterina S PrikhozhdenkoScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0003-2700-168X
Olga I GusliakovaScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0001-8387-0711
Svetlana V RaikovaDepartment of Microbiology, Virology and Immunology, Saratov State Medical University Named after V. I. Razumovsky, 112 Bolshaya Kazachia St., 410012 Saratov, Russia.ORCID 0000-0001-5749-2382
Timothy E L DouglasEngineering Department, Lancaster University, Gillow Av., Lancaster LA1 4YW, UK.ORCID 0000-0002-8069-8941
Olga A SindeevaCenter for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia.ORCID 0000-0002-5288-4157
Oksana A MayorovaScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0002-6440-3947
Saratov State University · RULancaster University · GBSaratov State Medical University · RUSkolkovo Institute of Science and Technology · RU

Funding

Russian Science Foundation 21-75-10042
6 · The paper itself

Abstract

Infectious sequelae caused by surgery are a significant problem in modern medicine due to their reduction of therapeutic effectiveness and the patients' quality of life.Recently, new methods of local antimicrobial prophylaxis of postoperative sequelae have been actively developed. They allow high local concentrations of drugs to be achieved, increasing the antibiotic therapy's effectiveness while reducing its side effects. We have developed and characterized antimicrobial hydrogels based on an inexpensive and biocompatible natural substance from the dairy industry-whey protein isolate-as matrices for drug delivery. The release of cefazolin from the pores of hydrogel structures directly depends on the amount of the loaded drug and occurs in a prolonged manner for three days. Simultaneously with the antibiotic release, hydrogel swelling and partial degradation occurs. The WPI hydrogels absorb solvent, doubling in size in three days and retaining cefazolin throughout the duration of the experiment. The antimicrobial activity of cefazolin-loaded WPI hydrogels against

Indexed as

antimicrobial activitycefazolindrug releasehydrogelwhey protein isolate

Identifiers

PMID35745772
PMCPMC9231275
OpenAlexW4281658670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.