ArticleEFSA journal. European Food Safety Authority2022
Assessment of the genotoxicity of acrylamide.
Article in EFSA journal. European Food Safety Authority, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Chemistry of Food Processing: Acrylamide in (Ultra-Processed) Food-A RASFF-Based Assessment.Toxics · 2026Article
- ATRA-mediated RAR-α activation attenuates acrylamide-induced testicular toxicity.Scientific reports · 2026Article
- Uptake and Biotransformation Govern the Toxicity of Reactive Acrylamides in anEnvironmental science & technology · 2026Article
- Balancing nutrition and safety: Acrylamide and HMF in biscuits from different cereal flours.Food chemistry: X · 2026Article
- Case Report: Ulcerative breast cancer occurring 20 years after breast augmentation with Amazingel injection.Frontiers in oncology · 2026Article
- Classical and New Approaches to Health Risk Assessment of Acrylamide Through the Consumption of Potato Chips.Food science & nutrition · 2025Article
- Cardiovascular health behaviour, acrylamide exposure and health risk assessment of adolescents.BMC public health · 2025Article
- Dose Responses to Supplemental Polyacrylamide on Digestion, Metabolism, and Ruminal Digestive-Enzyme Activities in Cattle.Life (Basel, Switzerland) · 2025Article
- Evaluating the Genotoxicity and Mutagenicity of Food Contaminants: Acrylamide, Penitrem A, and 3-Acetyldeoxynivalenol in Individual and Combined Exposure In Vitro.Journal of applied toxicology : JAT · 2025Article
- Dietary Acrylamide Exposure and Its Correlation with Nutrition and Exercise Behaviours Among Turkish Adolescents.Nutrients · 2025Article
- Acrylamide coadministration modulates hepatic ROS-mediated apoptotic DNA damage and inflammation induced by TiOScientific reports · 2025Article
- Enhancing Nutrient Profile and Reducing Acrylamide in California-Style Table Olives withFoods (Basel, Switzerland) · 2025Article
- Estimation of the Dietary Acrylamide Exposure of the Turkish Population: An Emerging Threat for Human Health.Nutrients · 2024Article
- Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to acrylamide (hemoglobin adducts, urinary mercapturic acids) and new insights on its endogenous formation.Archives of toxicology · 2024Article
- Results of the BfR MEAL Study: Acrylamide in foods from the German market with highest levels in vegetable crisps.Food chemistry: X · 2024Article
- Dietary Exposure to Acrylamide Has Negative Effects on the Gastrointestinal Tract: A Review.Nutrients · 2024Review
- Dietary Acrylamide: A Detailed Review on Formation, Detection, Mitigation, and Its Health Impacts.Foods (Basel, Switzerland) · 2024Review
- An exploratory study to assess the knowledge, attitudes and practices of Lebanese residents towards acrylamide.PloS one · 2024Article
- Estimation of genomic and mitochondrial DNA integrity in the renal tissue of mice administered with acrylamide and titanium dioxide nanoparticles.Scientific reports · 2023Article
- Reconstructed human intestinal comet assay, a possible alternative in vitro model for genotoxicity assessment.Mutagenesis · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EFSA was requested to deliver a statement on a recent publication revisiting the evidence for genotoxicity of acrylamide (AA). The statement was prepared by a Working Group and was endorsed by the CONTAM Panel before its final approval. In interpreting the Terms of Reference, the statement considered the modes of action underlying the carcinogenicity of AA including genotoxic and non-genotoxic effects. Relevant publications since the 2015 CONTAM Panel Opinion on AA in food were reviewed. Several new studies reported positive results on the clastogenic and mutagenic properties of AA and its active metabolite glycidamide (GA). DNA adducts of GA were induced by AA exposure in experimental animals and have also been observed in humans. In addition to the genotoxicity of AA, there is evidence for both secondary DNA oxidation via generation of reactive oxygen species and for non-genotoxic effects which may contribute to carcinogenesis by AA. These studies extend the information assessed by the CONTAM Panel in its 2015 Opinion, and support its conclusions. That Opinion applied the margin of exposure (MOE) approach, as recommended in the EFSA Guidance for substances that are both genotoxic and carcinogenic, for risk characterisation of the neoplastic effects of AA. Based on the new data evaluated, the MOE approach is still considered appropriate, and an update of the 2015 Opinion is not required at the present time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.