Evidence map›Paper›PMID 35508275›Full record

ReviewProgress in lipid research2022

Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions.

Simon C Dyall, Laurence Balas, Nicolas G Bazan, J Thomas Brenna, Nan Chiang, Felipe da Costa Souza, Jesmond Dalli, Thierry Durand, Jean-Marie Galano, Pamela J Lein and 2 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in lipid research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 348 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
348citing papers in PubMed, 3 pooled it
70.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

348 citing papers in PubMed, 3 syntheses or guidelines pooled it, 562 citations in OpenAlex.

  1. Pooled it
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  13. Vanadium(IV)-chlorodipicolinate alleviates hepatic steatosis via the AMPK/PGC-1α/CPT1a axis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
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  20. Lipidome of Endemic FishMembranes · 2026
    Article

288 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Simon C DyallSchool of Life and Health Sciences, University of Roehampton, London, UK. Electronic address: Simon.Dyall@roehampton.ac.uk.
Laurence BalasIBMM, University Montpellier, CNRS, ENSCM, Montpellier, France.
Nicolas G BazanNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.
J Thomas BrennaDepts of Pediatrics, of Chemistry and of Nutrition, Dell Pediatric Research Institute, University of Texas at Austin, TX, USA; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Nan ChiangCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Felipe da Costa SouzaDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA; Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.
Jesmond DalliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Thierry DurandIBMM, University Montpellier, CNRS, ENSCM, Montpellier, France.
Jean-Marie GalanoIBMM, University Montpellier, CNRS, ENSCM, Montpellier, France.
Pamela J LeinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Charles N SerhanCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ameer Y TahaDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.
University of California, Davis · USBrigham and Women's Hospital · USCentre National de la Recherche Scientifique · FRCornell University · USÉcole Nationale Supérieure de Chimie de Montpellier · FRInstitut des Biomolécules Max Mousseron · FRLouisiana State University Health Sciences Center New Orleans · USQueen Mary University of London · GBUniversity of Roehampton · GB

Funding

RPE Messengers, Transcription &Photoreceptor RenewalR01EY005121 · NEI · LSU HEALTH SCIENCES CENTER · PI Nicolas G. Bazan · 1985 to 2026
$9.1M
BLOOD CELL LIPOXYGENASE PRODUCTS: FORMATION AND ACTIONR01GM038765 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 1992 to 2020
$4.9M
Evaluating Resolution Mechanisms for Infectious InflammationR35GM139430 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2021 to 2025
$3.6M
Docosanoids modulate homeostasis and cell survival after ischemic strokeR01NS109221 · NINDS · LSU HEALTH SCIENCES CENTER · PI BAZAN, NICOLAS G., BELAYEV, LUDMILA S. · 2019 to 2023
$1.7M
Novel combinatory therapy for experimental ischemic strokeR01NS104117 · NINDS · LSU HEALTH SCIENCES CENTER · PI BAZAN, NICOLAS G., BELAYEV, LUDMILA S. · 2018 to 2022
$1.6M
Role of excess maternal linoleic acid intake on infant neurodevelopmentR21HD095391 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TAHA, AMEER · 2019 to 2020
$432k
NEI NIH HHS R01 EY005121NICHD NIH HHS R21 HD095391NIGMS NIH HHS R01 GM038765NIGMS NIH HHS R35 GM139430NINDS NIH HHS R01 NS104117NINDS NIH HHS R01 NS109221Wellcome TrustWellcome Trust 107613/Z/15/Z
6 · The paper itself

Abstract

Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids, and influence cellular function via effects on membrane properties, and also by acting as a precursor pool for lipid mediators. These lipid mediators are formed via activation of pathways involving at least one step of dioxygen-dependent oxidation, and are consequently called oxylipins. Their biosynthesis can be either enzymatically-dependent, utilising the promiscuous cyclooxygenase, lipoxygenase, or cytochrome P450 mixed function oxidase pathways, or nonenzymatic via free radical-catalyzed pathways. The oxylipins include the classical eicosanoids, comprising prostaglandins, thromboxanes, and leukotrienes, and also more recently identified lipid mediators. With the advent of new technologies there is growing interest in identifying these different lipid mediators and characterising their roles in health and disease. This review brings together contributions from some of those at the forefront of research into lipid mediators, who provide brief introductions and summaries of current understanding of the structure and functions of the main classes of nonclassical oxylipins. The topics covered include omega-3 and omega-6 PUFA biosynthesis pathways, focusing on the roles of the different fatty acid desaturase enzymes, oxidized linoleic acid metabolites, omega-3 PUFA-derived specialized pro-resolving mediators, elovanoids, nonenzymatically oxidized PUFAs, and fatty acid esters of hydroxy fatty acids.

Indexed as

Fatty AcidsFatty Acids, Omega-3EicosanoidsFatty Acids, UnsaturatedOxylipinsEicosanoidsFatty AcidsFatty Acids, Omega-3Fatty Acids, UnsaturatedOxylipinsElovanoidsFAHFAFatty acid desaturaseLipid mediatorsMaresinsOmega-3 PUFAOxylipinsProtectinsResolvinsSPM

Identifiers

PMID35508275
PMCPMC9346631
OpenAlexW4225278778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.