Evidence map›Paper›PMID 35267809›Full record

ReviewPolymers2022

Protein-Based Hydrogels: Promising Materials for Tissue Engineering.

Niyousha Davari, Negar Bakhtiary, Mehran Khajehmohammadi, Soulmaz Sarkari, Hamidreza Tolabi, Farnaz Ghorbani, Behafarid Ghalandari

Open access · goldAbstract readReview
In one paragraph

Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 92 citations in OpenAlex.

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  16. Considerations and implications of currentFrontiers in cell and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 3 countries.

Niyousha DavariDepartment of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran 143951561, Iran.ORCID 0000-0003-0197-781X
Negar BakhtiaryBurn Research Center, Iran University of Medical Sciences, Tehran 1449614535, Iran.ORCID 0000-0003-2771-0339
Mehran KhajehmohammadiDepartment of Mechanical Engineering, Faculty of Engineering, Yazd University, Yazd 8174848351, Iran.ORCID 0000-0002-2839-0210
Soulmaz SarkariDepartment of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran.ORCID 0000-0003-2099-3022
Hamidreza TolabiNew Technologies Research Center (NTRC), Amirkabir University of Technology, Tehran 158754413, Iran.ORCID 0000-0001-6496-3146
Farnaz GhorbaniInstitute of Biomaterials, Department of Material Science and Engineering, University of Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany.ORCID 0000-0001-9271-7874
Behafarid GhalandariState Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Amirkabir University of Technology · IRFriedrich-Alexander-Universität Erlangen-Nürnberg · DEIslamic Azad University, Science and Research Branch · IRShanghai Jiao Tong University · CNTarbiat Modares University · IRUniversity of Tehran · IRYazd University · IR

Funding

Alexander von Humboldt Foundation
6 · The paper itself

Abstract

The successful design of a hydrogel for tissue engineering requires a profound understanding of its constituents' structural and molecular properties, as well as the proper selection of components. If the engineered processes are in line with the procedures that natural materials undergo to achieve the best network structure necessary for the formation of the hydrogel with desired properties, the failure rate of tissue engineering projects will be significantly reduced. In this review, we examine the behavior of proteins as an essential and effective component of hydrogels, and describe the factors that can enhance the protein-based hydrogels' structure. Furthermore, we outline the fabrication route of protein-based hydrogels from protein microstructure and the selection of appropriate materials according to recent research to growth factors, crucial members of the protein family, and their delivery approaches. Finally, the unmet needs and current challenges in developing the ideal biomaterials for protein-based hydrogels are discussed, and emerging strategies in this area are highlighted.

Indexed as

interactionprotein-based hydrogelprotein structurestissue engineeringunfolding

Identifiers

PMID35267809
PMCPMC8914701
OpenAlexW4214637436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.