Evidence map›Paper›PMID 35111124›Full record

ArticleFrontiers in neurology2021

A Patient-Centered Evaluation of Meaningful Change on the 32-Item Motor Function Measure in Spinal Muscular Atrophy Using Qualitative and Quantitative Data.

Tina Duong, Hannah Staunton, Jessica Braid, Aurelie Barriere, Ben Trzaskoma, Ling Gao, Tom Willgoss, Rosangel Cruz, Nicole Gusset, Ksenija Gorni and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Current clinical applications of AAV-mediated gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  6. Swallowing function in patients with spinal muscular atrophy before and after the introduction of new gene-based therapies: what has changed?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  7. Observational
  8. Review
  9. Exploring variability in cognitive functioning in patients with spinal muscular atrophy: a scoping review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Tina DuongDepartment of Neurology, Stanford University, Stanford, CA, United States.
Hannah StauntonRoche Products Limited, Welwyn Garden City, United Kingdom.
Jessica BraidRoche Products Limited, Welwyn Garden City, United Kingdom.
Aurelie BarriereDepartment of Pediatric Physical Medicine and Rehabilitation, Hôpital Mère Enfant, Centre Hospitalier Universitaire (CHU)-Lyon, Lyon University, Lyon, France.
Ben TrzaskomaGenentech Inc., South San Francisco, CA, United States.
Ling GaoAnalystat Corporation, Point Roberts, WA, United States.
Tom WillgossRoche Products Limited, Welwyn Garden City, United Kingdom.
Rosangel CruzCure SMA, Elk Grove Village, IL, United States.
Nicole GussetSMA Europe, Freiburg, Germany.
Ksenija GorniProduct Development Medical Affairs, Neuroscience and Rare Disease, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Sharan RandhawaAdelphi Values, Patient-Centered Outcomes, Adelphi Mill, Bollington, United Kingdom.
Lida YangCharles River Associates Inc., Zurich, Switzerland.
Carole VuillerotNeuromyogen Institute, CNRS UMR 5310 INSERM U1217, Université de Lyon, Lyon, France.
Roche (United Kingdom) · GBAdelphi Group (United Kingdom) · GBCure Spinal Muscular Atrophy · USHôpital Mère-Enfant · FRInserm · FRRoche (Switzerland) · CHStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 32-item Motor Function Measure (MFM32) is an assessment of motor function used to evaluate fine and gross motor ability in patients with neuromuscular disorders, including spinal muscular atrophy (SMA). Reliability and validity of the MFM32 have been documented in individuals with SMA. Through semi-structured qualitative interviews (

Indexed as

32-item Motor Function Measure (MFM32)anchor-based methodsmeaningful changeonline surveyqualitative interviewsspinal muscular atrophy

Identifiers

PMID35111124
PMCPMC8802297
OpenAlexW4205657977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.