Evidence map›Paper›PMID 35079895›Full record

Trial reportEuropean journal of nutrition2022

Activation of gastrointestinal ileal brake response with dietary slowly digestible carbohydrates, with no observed effect on subjective appetite, in an acute randomized, double-blind, crossover trial.

Mohammad Chegeni, Anna M R Hayes, Tanhia D Gonzalez, Michelle M Manderfeld, Jongbin Lim, Ravi S Menon, Nort M Holschuh, Mary E Hedges, Bruce R Hamaker

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03630445 (Impact of Slowly Digestible Carbohydrates on Gastric Emptying Rate Suggests Activation of Ileal Brake Response), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03630445 nacompletednot on this map

Impact of Slowly Digestible Carbohydrates on Gastric Emptying Rate Suggests Activation of Ileal Brake Response

TypeinterventionalSponsorPurdue UniversityRan2015 to 2015Enrolled20ConditionsObesity, Diabetes Mellitus, Type 2, Appetitive BehaviorArmsIsomaltooligosaccharides (IMOs), Xtend® sucromalt, Combination of IMOs and Xtend® sucromalt, Raw corn starch, Maltodextrin
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. The [Lipids · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mohammad ChegeniWhistler Center for Carbohydrate Research and Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN, 47907, USA.
Anna M R HayesWhistler Center for Carbohydrate Research and Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN, 47907, USA.
Tanhia D Gonzalez *General Mills, Inc, 9000 Plymouth Avenue North, Minneapolis, MN, 55427, USA.
Michelle M ManderfeldGeneral Mills, Inc, 9000 Plymouth Avenue North, Minneapolis, MN, 55427, USA.
Jongbin LimWhistler Center for Carbohydrate Research and Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN, 47907, USA.
Ravi S MenonGeneral Mills, Inc, 9000 Plymouth Avenue North, Minneapolis, MN, 55427, USA.
Nort M HolschuhGeneral Mills, Inc, 9000 Plymouth Avenue North, Minneapolis, MN, 55427, USA.
Mary E HedgesGeneral Mills, Inc, 9000 Plymouth Avenue North, Minneapolis, MN, 55427, USA.
Bruce R HamakerWhistler Center for Carbohydrate Research and Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN, 47907, USA. hamakerb@purdue.edu.ORCID http://orcid.org/0000-0001-6591-942X
General Mills (United States) · USPurdue University West Lafayette · USUniversity of Saint Mary of the Lake · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo test the hypothesis that oral ingestion of slowly digestible carbohydrates (SDCs) that reach the ileum triggers the ileal brake as indicated by delayed gastric emptying, reduced glycemic response, and decreased subjective appetite.

methodsThe study was a five-arm, randomized, double-blind, crossover trial with a 1-week washout period between treatments (n = 20; 9 females, 11 males). Five treatments consisted of three SDC ingredients [raw corn starch, isomaltooligosaccharide (IMO), sucromalt], and an IMO/sucromalt combination, shown in vitro to have slow and extended digestion profiles, and a rapidly digestible carbohydrate control (maltodextrin). Carbohydrates (26 g) were incorporated into yogurt [300 g total; carbohydrate (~ 77 g), fat (~ 0.2 g), and protein (~ 9 g)] with closely matched energy content (346 kcal) and viscosity (~ 30,000 cP). Outcomes were measured in a 4 h postprandial period.

resultsMean gastric half-emptying times were moderately though significantly increased for the raw corn starch and IMO treatments (P < 0.05), but they could be sub-divided into larger effect responder (n = 11) and non-responder groups (n = 9). Longer time for glycemic response to return to baseline was associated with increased gastric half-emptying time in an exploratory subset of data removing gastric half-emptying times > 3.5 h (P = 0.02). No significant differences in appetite ratings were observed.

conclusionSDCs caused slower gastric emptying rate through activation of the ileal brake, as closely matched semi-solid yogurts were used and only rate of carbohydrate digestion differed. Extending glycemic response through consumption of SDCs was associated with triggering the ileal brake.

trial registrationClinicalTrials.gov NCT03630445, August 2018, retrospectively registered.

Indexed as

AppetiteDietary CarbohydratesBlood GlucoseCross-Over StudiesFemaleGastric EmptyingHumansIleumMalePostprandial PeriodStarchBlood GlucoseDietary CarbohydratesStarchAppetitive responseGastric emptyingGlycemic responseHuman participantsIleal brakeSlowly digestible carbohydrates

Identifiers

PMID35079895
OpenAlexW4210316434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.