Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial.

The primary results report of NCT04074161. Its numbers are set against the trial’s posted results below.

What the trial testedrandomised · 338 people · 2022

Randomised comparison

−9.40percentage points−12.0 to −6.80

As reported

difference −9.4 percentage points, 95% CI −12.0 to −6.80

Same as the trial’s posted resultThis paper difference −9.40 (−12.0 to −6.80)Posted, primary outcome difference −9.38 (−12.0 to −6.80), p <0.0001Change From Baseline (Week 0) to Week 68 in Body Weight (%) (Semaglutide 2.4 mg Versus Liraglutide 3.0 mg)

the abstract, start to end

… vs -6.4% with liraglutide (difference, -9.4 percentage points [95% CI, …

← favours treatmentfavours comparator →

could be chance

Body weight & composition

−9.4−12.0 to −6.80

GLP-1 receptor agonistsBody weight & composition

GLP-1 receptor agonists × body weight & compositionhelps?replicated

unlikelylikely

0.910.91 without it

← favours treatmentfavours comparator →

this papermore certainless certain

1 / 5

2022

…

2025

2026

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