Evidence map›Paper›PMID 34950249›Full record

ArticleDisease markers2021

The Degree of Plasma Oxidized Low-Density Lipoprotein Level Decrease Is Related to Clinical Outcomes for Patients with Acute Ischemic Stroke.

Xiaoli Yang, Wenbo Sun, Duanlu Hou, Tianyao Wang, Chen Li, Yufan Luo, Shufan Zhang, Liwei Shen, Wenpeng Liu, Danhong Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiaoli YangDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Wenbo SunDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Duanlu HouDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Tianyao WangRadiology Department, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Chen LiDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Yufan LuoDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Shufan ZhangDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Liwei ShenDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Wenpeng LiuDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-1462-073X
Danhong WuDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-1132-6669
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the relationship between the decrease of plasma oxidized low-density lipoprotein (oxLDL) levels and clinical outcomes in patients with acute atherosclerosis-related ischemic stroke.

methodsWe recruited acute ischemic stroke patients within 3 days of onset consecutively. Plasma oxLDL levels were measured on the second day after admission and before discharge (10-14 days after stroke onset). Initial stroke severity was assessed by the National Institutes of Health Stroke Scale (NIHSS) scores, and infarct volume was measured using diffusion-weighted imaging (DWI) by the ITK-SNAP software. Clinical outcomes were evaluated by DWI volumes in the acute phase, neurological improvement at discharge, and favorable functional prognosis at 90 days. Logistic regression was performed to evaluate the association between oxLDL level decrease and clinical outcomes.

results207 patients were enrolled in this study. Compared with the mild decrease of the oxLDL level group, patients with a significant decrease of the oxLDL level group were more likely to have a higher ratio of neurological improvement at discharge (55.07% vs. 14.49%,

conclusionsThe degree of oxLDL level decrease is related to neurological improvement at discharge and favorable functional prognosis at 90 days for patients with acute atherosclerosis-related ischemic stroke, but not with infarct volume in the acute phase.

Indexed as

Diffusion Magnetic Resonance ImagingPrognosisSeverity of Illness IndexAgedBrain IschemiaFemaleHumansIschemic StrokeLipoproteins, LDLMaleTime FactorsLipoproteins, LDLoxidized low density lipoprotein

Identifiers

PMID34950249
PMCPMC8692044
OpenAlexW4200013698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.