Evidence map›Paper›PMID 34836205›Full record

Trial reportNutrients2021

Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity.

Valentine Bordier, Fabienne Teysseire, Götz Schlotterbeck, Frank Senner, Christoph Beglinger, Anne Christin Meyer-Gerspach, Bettina K Wölnerhanssen

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Anti-Obesity Effects ofFood science & nutrition · 2025
    Article
  7. Re-evaluation of erythritol (E 968) as a food additive.EFSA journal. European Food Safety Authority · 2023
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Valentine BordierSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0002-1229-825X
Fabienne TeysseireSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0001-8602-9960
Götz SchlotterbeckInstitute for Chemistry and Bioanalytics, School of Life Science, FHNW University of Applied Sciences and Arts Northwestern Switzerland, 4132 Muttenz, Switzerland.
Frank SennerInstitute for Chemistry and Bioanalytics, School of Life Science, FHNW University of Applied Sciences and Arts Northwestern Switzerland, 4132 Muttenz, Switzerland.
Christoph BeglingerSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.
Anne Christin Meyer-GerspachSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0003-4104-8812
Bettina K WölnerhanssenSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0003-3134-2743

Funding

Fondation Botnar REG-19-001Freie akademische Gesellschaft n/aMedical Image Analysis Center n/a
6 · The paper itself

Abstract

In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute ingestion reduces intestinal glucose absorption. This study aims to investigate whether a chronic intake of xylitol and erythritol impacts glucose absorption in humans with obesity. Forty-six participants were randomized to take either 8 g of xylitol or 12 g of erythritol three times a day for five to seven weeks, or to be part of the control group (no substance). Before and after the intervention, intestinal glucose absorption was assessed during an oral glucose tolerance test with 3-

Indexed as

Absorption, PhysiologicalAdultErythritolFemaleGlucoseHumansMaleObesityXylitolErythritolGlucoseXylitol3-OMGerythritolglucose absorptionnatural sweetenersobesityxylitol

Identifiers

PMID34836205
PMCPMC8618859

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.