SynthesisBMC musculoskeletal disorders2021
Predictors of postoperative delirium in elderly patients following total hip and knee arthroplasty: a systematic review and meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05537155 (Buccal Acupuncture for Delirium Treatment in Older Patients Recovering From Orthopedic Surgery), which is not on this map. Cited by 43 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Buccal Acupuncture for Delirium Treatment in Older Patients Recovering From Orthopedic Surgery: a Randomized Controlled Trial
Who cites it
43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Cognitive Impairment and Postoperative Outcomes in Patients Undergoing Primary Total Hip Arthroplasty and Primary Total Knee Arthroplasty: A Systematic Review and Meta-analysis.Annals of African medicine · 2026Pooled it
- Comparison of the effects of remimazolam and propofol on postoperative delirium in elderly surgical patients: a meta-analysis.BMC anesthesiology · 2025Pooled it
- The role of diabetes mellitus on delirium onset: a systematic review and meta-analysis.Cardiovascular diabetology · 2025 · on this mapPooled it
- Efficacy and safety of esketamine in preventing perioperative neurocognitive disorders: a meta-analysis of randomized controlled studies.Systematic reviews · 2025Pooled it
- Incidence and factors associated with postoperative delirium after primary total joint arthroplasty in older adults: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Perioperative Factors Associated With Postoperative Delirium in Patients Undergoing Noncardiac Surgery: An Individual Patient Data Meta-Analysis.JAMA network open · 2023Pooled it
- Perineural dexamethasone effectively prolongs anaesthesic block duration in total hip arthroplasty, reduces opioid consumption, and does not compromise motor function, nerve integrity, or glycaemic control.International orthopaedics · 2025Trial
- Comparison of the safety and efficacy of desflurane versus sevoflurane on postoperative cognitive function and early recovery quality in elderly orthopedic patients: a prospective, randomized controlled trial.Frontiers in medicine · 2025Trial
- Effect of Ephedrine versus Phenylephrine on Postoperative Delirium in Elderly Patients Undergoing Total Hip or Knee Arthroplasty: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Impact of cognitive impairment on postoperative delirium and discharge disposition following knee arthroplasty: a Japanese nationwide propensity score-matched study.Archives of orthopaedic and trauma surgery · 2026Article
- Risk factors for delirium after hip arthroplasty: An umbrella meta-analysis.International journal of nursing studies advances · 2026Review
- Perioperative Outcomes of Cemented vs Cementless Total Hip Arthroplasty: A National Inpatient Sample Study of 81,668 Elective Procedures.Journal of clinical medicine · 2026Article
- Development and validation of a post-operative delirium prediction model for patients undergoing abdominal surgery: a retrospective, observational, single-center study.Perioperative medicine (London, England) · 2026Article
- Relevance and Feasibility of a "Geriatric Delirium Pass" for Older Patients with Elective Surgeries: Findings from a Multi-Methods Study.Geriatrics (Basel, Switzerland) · 2026Article
- A machine-learning-assisted logistic regression model for predicting post-operative delirium in older adults undergoing total knee arthroplasty.Frontiers in neurology · 2026Article
- Impact of circadian rhythm change on postoperative delirium in elderly patients undergoing lower extremity orthopedic surgery: a propensity score-matched prospective cohort study.Frontiers in medicine · 2026Article
- Postoperative delirium risk in elderly high-risk patients undergoing hip and knee arthroplasty (ASA Ⅲ-Ⅳ): construction and validation of a nomogram model based on frail frailty index.Frontiers in medicine · 2026Article
- Patient-reported outcomes as drivers of postoperative delirium in the postanaesthesia care unit: Data from a one-year prospective cohort study.European journal of anaesthesiology · 2025Article
- Delirium after cardiac arrest: incidence, risk factors, and association with neurologic outcome-insights from the Freiburg Delirium Registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Association between preoperative anemia and postoperative delirium in elderly patients undergoing non-cardiac surgery: a retrospective observational study.Korean journal of anesthesiology · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative delirium (POD) is widely reported as a common postoperative complication following total joint arthroplasty (TJA) of the hip and knee in elderly patients, leading to many adverse effects. We sought to investigate predictors of delirium after TJA.
methodsPubMed, EMBASE, Cochrane Library and Web of Science were searched up to 2020 for studies examining POD following TJA in elderly patients. Pooled odds ratio (OR) and mean difference (MD) of those who experienced delirium compared to those who did not were calculated for each variable. The Newcastle-Ottawa Scale (NOS) was used for the study quality evaluation.
resultsFifteen studies with 31 potential factors were included. In the primary analysis, 9 factors were associated with POD, comprising advanced age (MD 3.81; 95% confidence interval (CI) 1.80-5.83), dementia (OR 24.85; 95% CI 7.26-85.02), hypertension (OR 2.26; 95% CI 1.31-3.89), diabetes (OR 2.02; 95% CI 1.15-3.55), stroke (OR 14.61; 95% CI 5.26-40.55), psychiatric illness (OR 2.72; 95% CI 1.45-5.08), use of sedative-hypnotics (OR 6.42; 95% CI 2.53-16.27), lower preoperative levels of hemoglobin (MD - 0.56; 95% CI - 0.89-- 0.22), and lower preoperative mini-mental state examination score (MD - 0.40; 95% CI - 0.69-- 0.12). Twelve studies were included in the systematic review, of which 24 factors were additionally correlated with POD using single studies.
conclusionsStrategies and interventions should be implemented for the elderly patients receiving TJA surgeries with potential predictors identified in this meta-analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.