Evidence map›Paper›PMID 34429413›Full record

ArticleNature communications2021

Engineered whole cut meat-like tissue by the assembly of cell fibers using tendon-gel integrated bioprinting.

Dong-Hee Kang, Fiona Louis, Hao Liu, Hiroshi Shimoda, Yasutaka Nishiyama, Hajime Nozawa, Makoto Kakitani, Daisuke Takagi, Daijiro Kasa, Eiji Nagamori and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 286 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Bioprocess Engineering for Cultivated Meat.Advances in biochemical engineering/biotechnology · 2026
    Review
  12. Edible Scaffolds for Cultivated Meat Production.Advances in biochemical engineering/biotechnology · 2026
    Review
  13. Probiotic-Based Materials as Living Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Dong-Hee KangDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan.
Fiona LouisJoint Research Laboratory (TOPPAN INC.) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan.ORCID 0000-0002-2453-2314
Hao LiuDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan.
Hiroshi ShimodaDepartment of Anatomical Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Yasutaka NishiyamaNH Foods, Ltd., Tsukuba, Japan.
Hajime NozawaKirin Central Research Institute, Kirin Holdings Company, Ltd., Fujisawa, Japan.
Makoto KakitaniKirin Central Research Institute, Kirin Holdings Company, Ltd., Fujisawa, Japan.
Daisuke TakagiBiomedical Business Center, Healthcare Business Group, Ricoh Company, Ltd., Kawasaki-shi, Japan.
Daijiro KasaSolution Planning, Product Solution Technologies, Production Printing, Industrial Solutions, Ricoh Japan Corporation, Tokyo, Japan.
Eiji NagamoriDepartment of Biomedical Engineering, Faculty of Engineering, Osaka Institute of Technology, Osaka, Japan.
Shinji IrieJoint Research Laboratory (TOPPAN INC.) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan.
Shiro KitanoJoint Research Laboratory (TOPPAN INC.) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan.
Michiya MatsusakiDivision of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan. m-matsus@chem.eng.osaka-u.ac.jp.ORCID 0000-0003-4294-9313
The University of Osaka · JPKirin (Japan) · JPRicoh (Japan) · JPFood Research Institute · JPHirosaki University · JPOsaka Institute of Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the current interest in cultured meat, mammalian cell-based meat has mostly been unstructured. There is thus still a high demand for artificial steak-like meat. We demonstrate in vitro construction of engineered steak-like tissue assembled of three types of bovine cell fibers (muscle, fat, and vessel). Because actual meat is an aligned assembly of the fibers connected to the tendon for the actions of contraction and relaxation, tendon-gel integrated bioprinting was developed to construct tendon-like gels. In this study, a total of 72 fibers comprising 42 muscles, 28 adipose tissues, and 2 blood capillaries were constructed by tendon-gel integrated bioprinting and manually assembled to fabricate steak-like meat with a diameter of 5 mm and a length of 10 mm inspired by a meat cut. The developed tendon-gel integrated bioprinting here could be a promising technology for the fabrication of the desired types of steak-like cultured meats.

Indexed as

GelsMeatTendonsAnimalsBioprintingCattleCell Culture TechniquesCollagenEndothelial CellsMusclesPrinting, Three-DimensionalStem CellsTissue EngineeringCollagenGels

Identifiers

PMID34429413
PMCPMC8385070
OpenAlexW3194240609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.