Evidence map›Paper›PMID 34347857›Full record

ReviewJournal of food protection2021

Occurrence of Ethyl Carbamate in Foods and Beverages: Review of the Formation Mechanisms, Advances in Analytical Methods, and Mitigation Strategies.

Eileen Abt, Victoria Incorvati, Lauren Posnick Robin, Benjamin W Redan

Abstract readReview
In one paragraph

Review in Journal of food protection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Food Biotechnology Potential of Grape-DerivedFoods (Basel, Switzerland) · 2026
    Article
  2. Microbial plastic degradation: enzymes, pathways, challenges, and perspectives.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  3. Article
  4. Review
  5. The Use of Non-Conventional Yeast in Sake Production.Molecules (Basel, Switzerland) · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Features and application potential of microbial urethanases.Applied microbiology and biotechnology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Eileen AbtU.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Safety, 6502 South Archer Road, Bedford Park, Illinois 60501, USA.
Victoria IncorvatiU.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Safety, 6502 South Archer Road, Bedford Park, Illinois 60501, USA.
Lauren Posnick RobinU.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Safety, 6502 South Archer Road, Bedford Park, Illinois 60501, USA.
Benjamin W RedanU.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Safety, 6502 South Archer Road, Bedford Park, Illinois 60501, USA.ORCID 0000-0002-2834-4468

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

abstractEthyl carbamate (EC) is a process contaminant that can be formed as a by-product during fermentation and processing of foods and beverages. Elevated EC concentrations are primarily associated with distilled spirits, but this compound has also been found at lower concentrations in foods and beverages, including breads, soy sauce, and wine. Evidence from animal studies suggests that EC is a probable human carcinogen. Consequently, several governmental institutions have established allowable limits for EC in the food supply. This review includes EC formation mechanisms, occurrence of EC in the food supply, and EC dietary exposure assessments. Current analytical methods used to detect EC will be covered, in addition to emerging technologies, such as nanosensors and surface-enhanced Raman spectroscopy. Various mitigation methods have been used to maintain EC concentrations below allowable limits, including distillation, enzymatic treatments, and genetic engineering of yeast. More research in this field is needed to refine mitigation strategies and develop methods to rapidly detect EC in the food supply. HIGHLIGHTS:

Indexed as

UrethaneWineAlcoholic BeveragesAnimalsBeveragesCarcinogensHumansCarcinogensUrethaneDistilled spiritsExposure assessmentGas chromatography–mass spectrometryProcess contaminantThermal processingUrethane

Identifiers

PMID34347857
PMCPMC9092314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.