Evidence map›Paper›PMID 34242372›Full record

ArticlePloS one2021

Vitamin D deficiency and severity of pneumonia in Indonesian children.

Vicka Oktaria, Rina Triasih, Stephen M Graham, Julie E Bines, Yati Soenarto, Michael W Clarke, Mike Lauda, Margaret Danchin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. The Role of Vitamin D in Supporting Health in the COVID-19 Era.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Vicka OktariaFaculty Medicine, Department of Paediatrics, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.ORCID 0000-0002-3556-3028
Rina TriasihFaculty of Medicine, Center for Child Health-Pediatric Research Office (CCH_PRO), Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Stephen M GrahamFaculty Medicine, Department of Paediatrics, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.
Julie E BinesFaculty Medicine, Department of Paediatrics, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.
Yati SoenartoFaculty of Medicine, Center for Child Health-Pediatric Research Office (CCH_PRO), Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Michael W ClarkeFaculty of Health, and Medical Sciences, Metabolomics Australia, Centre for Microscopy, Characterisation, and Analysis, and School of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia.
Mike LaudaFaculty of Medicine, Child Health Department, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia.
Margaret DanchinFaculty Medicine, Department of Paediatrics, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.
Royal Children's Hospital · AUUniversitas Gadjah Mada · IDThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the prevalence of vitamin D deficiency in Indonesian children hospitalized with pneumonia and evaluate the association between vitamin D status and severity of pneumonia.

methodsA hospital-based cross-sectional study was conducted from February 2016 to July 2017 in two district hospitals in Yogyakarta province, Indonesia. Infants and young children aged 2-59 months hospitalized with pneumonia were recruited. Serum blood samples were collected on admission and analyzed for total serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 concentrations using liquid chromatography-tandem mass spectrometry. Vitamin D deficiency was defined as a level of serum vitamin D <50 nmol/L. The association between vitamin D deficiency and severity of hospitalized pneumonia according to WHO criteria, including the presence of danger signs, hypoxemia (SpO2 in air below 90%), duration of hospitalization, and admission to Intensive Care Unit (ICU), was analyzed using logistic regression.

results133 children with WHO-defined pneumonia were enrolled in the study and 127 (96%) had their vitamin D status determined. The mean vitamin D concentration was 67 (± 24 SD) nmol/L and 19% of participants were vitamin D deficient. Age younger than 6 months was associated with prolonged hospitalization (> 5 days) and low birth weight and poor nutritional status on admission were risk factors for hypoxemia. However, vitamin D status was not associated with the presence of danger signs, duration of hospitalization, or hypoxemia.

conclusionsOne in every five children hospitalized with pneumonia was vitamin D deficient. Vitamin D status was not associated with the severity of pneumonia.

Indexed as

ChildChild, PreschoolFemaleHumansIndonesiaInfantMalePneumoniaVitamin DVitamin D DeficiencyVitamin D

Identifiers

PMID34242372
PMCPMC8270442
OpenAlexW3179983536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.