Evidence map›Paper›PMID 34200426›Full record

ArticleFoods (Basel, Switzerland)2021

Investigation of Immunomodulatory and Gut Microbiota-Altering Properties of Multicomponent Nutraceutical Prepared from Lactic Acid Bacteria, Bovine Colostrum, Apple Production By-Products and Essential Oils.

Juozas Grigas, Modestas Ruzauskas, Arnoldas Pautienius, Elena Bartkiene, Vita Lele, Vytaute Starkute, Paulina Zavistanaviciute, Egle Zokaityte, Jurga Bernatoniene, Liudas Ivanauskas and 2 more

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Juozas GrigasLaboratory of Immunology, Department of Anatomy and Physiology, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.ORCID 0000-0003-2450-5700
Modestas RuzauskasLaboratory of Immunology, Department of Anatomy and Physiology, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.ORCID 0000-0002-1040-0249
Arnoldas PautieniusLaboratory of Immunology, Department of Anatomy and Physiology, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.ORCID 0000-0002-4494-2724
Elena BartkieneDepartment of Food Safety and Quality, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.ORCID 0000-0003-3706-1280
Vita LeleDepartment of Food Safety and Quality, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.
Vytaute StarkuteDepartment of Food Safety and Quality, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.
Paulina ZavistanaviciuteDepartment of Food Safety and Quality, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.
Egle ZokaityteDepartment of Food Safety and Quality, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.ORCID 0000-0001-8081-4482
Jurga BernatonieneInstitute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Sukilėlių Pr. 13, LT-50162 Kaunas, Lithuania.ORCID 0000-0003-1744-2932
Liudas IvanauskasDepartment of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, Sukilėlių Pr. 13, LT-50162 Kaunas, Lithuania.ORCID 0000-0001-5390-2161
Valdas JakstasInstitute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Sukilėlių Pr. 13, LT-50162 Kaunas, Lithuania.ORCID 0000-0001-7627-6263
Arunas StankeviciusLaboratory of Immunology, Department of Anatomy and Physiology, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

European Regional Development Fund No 01.2.2-LMT-K-718-01-0062
6 · The paper itself

Abstract

Dietary components, such as lactic acid bacteria (LAB), bovine colostrum, apple production by-products, and essential oils, can favorably alter the host immune system and gut microbiota, however, their cumulative effect as multicomponent nutraceutical supplement has not been investigated. Therefore, the present study is the first one to evaluate a combination of LAB, bovine colostrum, dehydrated apple pomace, and essential oils for their immunomodulatory and prebiotic properties in the swine model. This study shows that supplementary feeding of pigs using multicomponent nutraceutical resulted in a statistically significant decrease in proportions of T cytotoxic and double-positive (CD4

Indexed as

applebovine colostrumessential oilimmunomodulationlactic acid bacteriamicrobiotanutraceuticalprebiotic

Identifiers

PMID34200426
PMCPMC8229151
OpenAlexW3172113666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.