ReviewFrontiers in aging neuroscience2021
Delirium: A Marker of Vulnerability in Older People.
Review in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
EXPLORING the CORRELATION of the LUNG ULTRASOUND with DELIRIUM and OUTCOMES in ACUTE GERIATRICS WORLD (ECO-AGE): a MULTICENTER, PROSPECTIVE, OBSERVATIONAL STUDY from the GRETA GROUP (GRUPPO DI RICERCA in ECOGRAFIA TORACICA NELL' ANZIANO) of the ITALIAN SOCIETY of GERONTOLOGY and GERIATRICS (SIGG)
Quasi-experimental Pre-post Study Assessing the Impact of Non-pharmacological Interventions Based on Nursing Care and of an Educational Programme for Delirium Prevention in Older Adults With Cognitive Frailty During Hospitalization
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Association between frailty and postoperative delirium after transcatheter aortic valve replacement: a meta-analysis.Frontiers in psychiatry · 2026Pooled it
- The role of diabetes mellitus on delirium onset: a systematic review and meta-analysis.Cardiovascular diabetology · 2025 · on this mapPooled it
- The effect of non-steroidal anti-inflammatory drugs on postoperative delirium: a meta-analysis.Korean journal of anesthesiology · 2024Pooled it
- Educational interventions aimed at improving knowledge of delirium among nursing home staff-a realist review.BMC geriatrics · 2024Pooled it
- Depression and Risk of Delirium in Older Adults: A Retrospective Cohort Study Using German Primary Care Data.Geriatrics (Basel, Switzerland) · 2026Article
- From Sensory Deprivation to Psychosis: Environmental Mechanisms of Delirium in Dementia-An Eight-Year Retrospective Longitudinal Case Report and Narrative Review.Healthcare (Basel, Switzerland) · 2026Article
- Demographics, clinical features and outcomes of older patients presenting to an Irish emergency department.Irish journal of medical science · 2026Article
- Bridging the gap in delirium management: a European comparison of geriatric practices.European geriatric medicine · 2026Article
- Observational
- Holistic Psychotherapeutic Approach in Elderly Burn Patients: A Consultation-liaison Psychiatry Case Series Integrating Supportive, Family-involved and Spiritual Interventions.Annals of burns and fire disasters · 2026Article
- Delirium Screening in the Emergency Department: Barriers, Enablers and Alignment With Clinical Standards-A Mixed-Methods Study.Emergency medicine Australasia : EMA · 2026Article
- CSF neurofilament light chain concentration in patients with delirium following hip fracture: a multicenter prospective study.BMC geriatrics · 2026Observational
- A rehabilitation intervention to improve recovery after delirium in older people: mixed methods process evaluation of the RecoverED multi-site feasibility study.BMC geriatrics · 2026Article
- Recommendations from the European interdisciplinary council on ageing on physical activity and diet for mental health conditions in older adults.Aging clinical and experimental research · 2026Review
- Effectiveness of Music Therapy for Delirium in Acute Hospital Settings: A Scoping Review.Nursing reports (Pavia, Italy) · 2026Review
- Association between pregabalin use and delirium in critically ill patients aged 60 and older: a retrospective analysis of the MIMIC-IV database.Open medicine (Warsaw, Poland) · 2026Article
- Article
- Article
- Prediction of postoperative delirium in older adults from preoperative cognition and occipital alpha power from resting-state electroencephalogram.Age and ageing · 2025Observational
- High prevalence of unrecognized postoperative delirium in elderly patients: a prospective cohort study from a resource-limited country.Patient safety in surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delirium is an acute neuropsychiatric syndrome and one of the most common presenting symptoms of acute medical illnesses in older people. Delirium can be triggered by a single cause, but in most cases, it is multifactorial as it depends on the interaction between predisposing and precipitating factors. Delirium is highly prevalent in older patients across various settings of care and correlates with an increased risk of adverse clinical outcomes. Several pathophysiological mechanisms may contribute to its onset, including neurotransmitter imbalance, neuroinflammation, altered brain metabolism, and impaired neuronal network connectivity. Several screening and diagnostic tools for delirium exist, but they are unfortunately underutilized. Additionally, the diagnosis of delirium superimposed on dementia poses a formidable challenge - especially if dementia is severe. Non-pharmacological approaches for the prevention and multidomain interventions for the treatment of delirium are recommended, given that there is currently no robust evidence of drugs that can prevent or resolve delirium. This article aims to review the current understanding about delirium in older people. To achieve this goal, we will describe the epidemiology and outcomes of the syndrome, the pathophysiological mechanisms that are supposed to be involved, the most commonly used tools for screening and diagnosis, and prevention strategies and treatments recommended. This review is intended as a brief guide for clinicians in hospital wards to improve their knowledge and practice. At the end of the article, we propose an approach to improve the quality of care provided to older patients throughout a systematic detection of delirium.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.