ArticleMaterials (Basel, Switzerland)2021
Composites Based on Hydroxyapatite and Whey Protein Isolate for Applications in Bone Regeneration.
Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Article
- Effect of Poly-γ-Glutamic Acid Molecular Weight on the Properties of Whey Protein Isolate Hydrogels.Polymers · 2025Article
- Article
- Hybrid Coatings Based on Polyvinylpyrrolidone/Polyethylene Glycol Enriched with Collagen and Hydroxyapatite: Incubation Studies and Evaluation of Mechanical and Physiochemical Properties.Journal of functional biomaterials · 2024Article
- Bioactive Hydrogel Based on Collagen and Hyaluronic Acid Enriched with Freeze-Dried Sheep Placenta for Wound Healing Support.International journal of molecular sciences · 2024Article
- The Enrichment of Whey Protein Isolate Hydrogels with Poly-γ-Glutamic Acid Promotes the Proliferation and Osteogenic Differentiation of Preosteoblasts.Gels (Basel, Switzerland) · 2023Article
- Comparison of three different lactic acid bacteria-fermented proteins on RAW 264.7 osteoclast and MC3T3-E1 osteoblast differentiation.Scientific reports · 2023Article
- Whey Protein Isolate/Calcium Silicate Hydrogels for Bone Tissue Engineering Applications-Preliminary In Vitro Evaluation.Materials (Basel, Switzerland) · 2023Article
- Influence of Drying Technique on Physicochemical Properties of Synthetic Hydroxyapatite and Its Potential Use as a Drug Carrier.Materials (Basel, Switzerland) · 2023Article
- 3D and 4D printing hydroxyapatite-based scaffolds for bone tissue engineering and regeneration.Heliyon · 2023Review
- Screw Osteointegration-Increasing Biomechanical Resistance to Pull-Out Effect.Materials (Basel, Switzerland) · 2023Review
- Characterization of a Graphene Oxide-Reinforced Whey Hydrogel as an Eco-Friendly Absorbent for Food Packaging.Gels (Basel, Switzerland) · 2023Article
- Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine.Nanomaterials (Basel, Switzerland) · 2022Article
- Effects of Sterilization and Hydrolytic Degradation on the Structure, Morphology and Compressive Strength of Polylactide-Hydroxyapatite Composites.International journal of molecular sciences · 2022Article
- Fabrication and Characterization of Submicron-Scale Bovine Hydroxyapatite: A Top-Down Approach for a Natural Biomaterial.Materials (Basel, Switzerland) · 2022Article
- The Ability and Mechanism of nHAC/CGF in Promoting Osteogenesis and Repairing Mandibular Defects.Nanomaterials (Basel, Switzerland) · 2022Article
- Preparation, Characterization, and Biocompatibility Assessment of Polymer-Ceramic Composites Loaded withMaterials (Basel, Switzerland) · 2021Article
- Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review.Cancers · 2021Review
- Various Simulated Body Fluids Lead to Significant Differences in Collagen Tissue Engineering Scaffolds.Materials (Basel, Switzerland) · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
Hydroxyapatite (HAp) is a bioactive ceramic with great potential for the regeneration of the skeletal system. However, its mechanical properties, especially its brittleness, limit its application. Therefore, in order to increase its ability to transmit stresses, it can be combined with a polymer phase, which increases its strength without eliminating the important aspect of bioactivity. The presented work focuses on obtaining organic-inorganic hydrogel materials based on whey protein isolate (WPI) reinforced with nano-HAp powder. The proportion of the ceramic phase was in the range of 0-15%. Firstly, a physicochemical analysis of the materials was performed using XRD, FT-IR and SEM. The hydrogel composites were subjected to swelling capacity measurements, potentiometric and conductivity analysis, and in vitro tests in four liquids: distilled water, Ringer's fluid, artificial saliva, and simulated body fluid (SBF). The incubation results demonstrated the successful formation of new layers of apatite as a result of the interaction with the fluids. Additionally, the influence of the materials on the metabolic activity according to ISO 10993-5:2009 was evaluated by identifying direct contact cytotoxicity towards L-929 mouse fibroblasts, which served as a reference. Moreover, the stimulation of monocytes by hydrogels via the induction of nuclear factor (NF)-κB was investigated. The WPI/HAp composite hydrogels presented in this study therefore show great potential for use as novel bone substitutes.
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