Evidence map›Paper›PMID 33769805›Full record

ArticleACS nano2021

Controlled Pulmonary Delivery of Carrier-Free Budesonide Dry Powder by Atomic Layer Deposition.

Damiano La Zara, Feilong Sun, Fuweng Zhang, Frans Franek, Kinga Balogh Sivars, Jenny Horndahl, Stephanie Bates, Marie Brännström, Pär Ewing, Michael J Quayle and 3 more

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Damiano La ZaraDepartment of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, Delft, 2629HZ, The Netherlands.ORCID 0000-0002-0967-7451
Feilong SunDepartment of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, Delft, 2629HZ, The Netherlands.ORCID 0000-0002-4612-5007
Fuweng ZhangDepartment of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, Delft, 2629HZ, The Netherlands.ORCID 0000-0002-0083-8415
Frans FranekAdvanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden.ORCID 0000-0001-5605-4655
Kinga Balogh SivarsClinical Testing and Precision Medicine, Global Procurement, Operations, AstraZeneca, Gothenburg, Sweden.ORCID 0000-0003-1150-2455
Jenny HorndahlBioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Stephanie BatesFunctional and Mechanistic Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge U.K.
Marie BrännströmDrug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Pär EwingDrug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Michael J QuayleNew Modalities and Parenteral Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Gothenburg, Sweden.ORCID 0000-0001-5782-6506
Gunilla PeterssonInnovation Strategy and External Liaison, Pharmaceutical Technology & Development, Operations, AstraZeneca, Gothenburg, Sweden.ORCID 0000-0003-0957-6113
Staffan FolestadInnovation Strategy and External Liaison, Pharmaceutical Technology & Development, Operations, AstraZeneca, Gothenburg, Sweden.ORCID 0000-0001-8069-6156
J Ruud van OmmenDepartment of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, Delft, 2629HZ, The Netherlands.ORCID 0000-0001-7884-0323
AstraZeneca (Sweden) · SEDelft University of Technology · NLAstraZeneca (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ideal controlled pulmonary drug delivery systems provide sustained release by retarding lung clearance mechanisms and efficient lung deposition to maintain therapeutic concentrations over prolonged time. Here, we use atomic layer deposition (ALD) to simultaneously tailor the release and aerosolization properties of inhaled drug particles without the need for lactose carrier. In particular, we deposit uniform nanoscale oxide ceramic films, such as Al

Indexed as

BudesonideSilicon DioxideAdministration, InhalationAerosolsHumansLactoseLungParticle SizePowdersAerosolsBudesonideLactosePowdersSilicon Dioxideatomic layer depositionbudesonidecontrolled releasedry powder inhalerinhalationisolated perfused rat lungparticle-to-cell deposition

Identifiers

PMID33769805
PMCPMC8155342
OpenAlexW3139160139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.