ReviewCells2021
Spermine: Its Emerging Role in Regulating Drought Stress Responses in Plants.
Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 160 citations in OpenAlex.
- Synergistic application of taurine and spermidine enhances wheat tolerance to neodymium stress through redox homeostasis, metabolic adjustment, and nutrient regulation.Plant signaling & behavior · 2026Article
- Green-synthesized lanthanum nanostructures modulate redox balance and phytochemical responses in lead-stressed Zataria multiflora.BMC plant biology · 2026Article
- Dual functions of thermospermine in plant growth and stress responses.Amino acids · 2026Review
- Phytohormones as key regulators of plant resilience under salinity and extreme temperatures.Planta · 2026Review
- Hydrogel-Based Controlled Release of Phytohormones: Improving Bioavailability and Early Plant Development Outcomes.International journal of molecular sciences · 2026Review
- Synergistic Enhancement of Phenolic Accumulation, Antioxidant Capacity and Fruit Quality in Marselan Grape (Vitis vinifera cv. Marselan) by Nano Zero-Valent Iron Combined with Potassium Dihydrogen Phosphat.Plants (Basel, Switzerland) · 2026Article
- Molecular characterization of SnRK2 gene family in Capsicum chinense and functional validation of CcSnRK2.5 under drought stress.Plant cell reports · 2026Article
- Investigating the impact of carbamazepine on tomato plant metabolism using genome-scale metabolic modelling.Scientific reports · 2026Article
- Role of Altered Metabolites and Metabolic Pathways in Major Tuber Crops Under Drought Stress.Plant-environment interactions (Hoboken, N.J.) · 2026Review
- Polyamine-mediated crosstalk in plant-microbe systems: implications for stress tolerance and crop protection.Frontiers in plant science · 2026Review
- Insect-Spinach Waste Synergy: EnhancingACS omega · 2025Article
- Trans-Zeatin EnhancesMicroorganisms · 2025Article
- Integrating metabolomics and high-throughput phenotyping to elucidate metabolic and phenotypic responses to early-season drought stress in Nordic spring wheat.BMC plant biology · 2025Article
- Spermine treatment improves salinity tolerance in Plantago major by altering growth parameters, biochemical profiles and gene expression.Scientific reports · 2025Article
- Gamma-Aminobutyric Acid: A Novel Biomolecule to Improve Plant Resistance and Fruit Quality.Plants (Basel, Switzerland) · 2025Review
- A global assembly of landrace oat (Avena sativa L.) accessions is a discovery resource for adaptive variation, association mapping, and trait deployment.G3 (Bethesda, Md.) · 2025Article
- Role of melatonin in promoting growth attributes, thymol, rosmarinic acid and biochemical properties in Thymus vulgaris L. under water deficiency.BMC plant biology · 2025Article
- A novel approach in using insect-based spinach-food waste for gene targeting to cancer tissues.Scientific reports · 2025Article
- Regulation of lignan biosynthesis through signaling pathways mediated by HScientific reports · 2025Article
- Polyamines Interaction with Gaseous Signaling Molecules for Resilience Against Drought and Heat Stress in Plants.Plants (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, research on spermine (Spm) has turned up a lot of new information about this essential polyamine, especially as it is able to counteract damage from abiotic stresses. Spm has been shown to protect plants from a variety of environmental insults, but whether it can prevent the adverse effects of drought has not yet been reported. Drought stress increases endogenous Spm in plants and exogenous application of Spm improves the plants' ability to tolerate drought stress. Spm's role in enhancing antioxidant defense mechanisms, glyoxalase systems, methylglyoxal (MG) detoxification, and creating tolerance for drought-induced oxidative stress is well documented in plants. However, the influences of enzyme activity and osmoregulation on Spm biosynthesis and metabolism are variable. Spm interacts with other molecules like nitric oxide (NO) and phytohormones such as abscisic acid, salicylic acid, brassinosteroids, and ethylene, to coordinate the reactions necessary for developing drought tolerance. This review focuses on the role of Spm in plants under severe drought stress. We have proposed models to explain how Spm interacts with existing defense mechanisms in plants to improve drought tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.