Evidence map›Paper›PMID 33505492›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

The Antioxidant and Anti-Inflammatory Effects of

Mahvash Alizade Naini, Shayan Mehrvarzi, Asal Zargari-Samadnejadi, Nader Tanideh, Mohammad Ghorbani, Amirreza Dehghanian, Maryam Hasanzarrini, Farnaz Banaee, Omid Koohi-Hosseinabadi, Cambyz Irajie and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  9. Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mahvash Alizade NainiGastroenterhepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0003-3025-0986
Shayan MehrvarziStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0002-9286-6455
Asal Zargari-SamadnejadiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0002-4682-5679
Nader TanidehStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0001-9282-1778
Mohammad GhorbaniHealth Sciences Research Center, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Amirreza DehghanianTrauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0003-0360-7468
Maryam HasanzarriniDepartment of Internal Medicine, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
Farnaz BanaeeDepartment of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0003-3360-6140
Omid Koohi-HosseinabadiCentral Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran.
Cambyz IrajieDepartment of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0001-8438-2146
Aida IrajiCentral Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0002-8442-2205
Shiraz University of Medical Sciences · IRHamedan University of Medical Sciences · IRTorbat Heydarieh University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesUlcerative colitis is a common subtype of persistent inflammatory bowel disease with high morbidity consequences. Despite unknown definite pathogenesis, multiple anti-inflammatory medications are used for its treatment. Traditionally, MATERIALS AND

methodsThis experimental study was designed to assess the possible therapeutic effects of QB on UC and compare its effects with those of sulfasalazine. Of the 70 Wistar rats clustered in seven groups, ten received only alcohols and sixty were confirmed to be suffering from trinitrobenzene sulfonic acid- (TNBS-) induced colitis. Four groups received different dosages of QB extract via oral and rectal routes, one received sulfasalazine, and the other remaining two groups received nothing. The effects of QB were evaluated by assessing macroscopic and histologic scoring, measuring inflammatory mediators, and determining oxidative stress markers.

resultsComparing to the untreated TNBS-induced control groups, QB-treated groups showed a dose- and route-dependent improvement comparable with sulfasalazine. Treating rats with QB reduced the microscopic and macroscopic damage, decreased TNF-

conclusionsOur data recommended the anti-inflammatory and antioxidant effects of QB extract in a dose-dependent manner.

Identifiers

PMID33505492
PMCPMC7808820
OpenAlexW3120568157

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.