Evidence map›Paper›PMID 33228978›Full record

Observational studyBritish journal of anaesthesia2021

Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study.

Tyler Ballweg, Marissa White, Margaret Parker, Cameron Casey, Amber Bo, Zahra Farahbakhsh, Austin Kayser, Alexander Blair, Heidi Lindroth, Robert A Pearce and 4 more

3 registry-linked trialsOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in British journal of anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 104 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 9 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02926417 completednot on this map

Interventions for Postoperative Delirium: Biomarker-2 (IPOD-B2) Pilot Study

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2016 to 2019Enrolled32ConditionsDeliriumArmsHigh Density-Electroencephalogram
NCT03124303 recruitingnot on this map

Interventions for Postoperative Delirium: Biomarker-3

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2017 to 2029Enrolled468ConditionsDeliriumArmsHigh Density-Electroencephalogram, Magnetic Resonance Imaging, Blood specimen collection, Pupillometry
NCT06366412 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Dexmedetomidine on Serum Tau-217 Protein as a Biomarker for Post-operative Cognitive Dysfunction in Elderly Patients.

TypeinterventionalSponsorMinia University HospitalRan2024 to 2026Enrolled94ConditionsCognitive ImpairmentArmsDexmedetomidine Hydrochloride, normal saline
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 9 syntheses or guidelines pooled it, 155 citations in OpenAlex.

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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Tyler BallwegDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Marissa WhiteDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Margaret ParkerDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Cameron CaseyDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Amber BoDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Zahra FarahbakhshDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Austin KayserDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Alexander BlairDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Heidi LindrothDepartment of Medicine, Indiana University School of Medicine, Center for Aging Research, Center for Health Innovation and Implementation, Indianapolis, IN, USA.
Robert A PearceDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK.
Richard LennertzDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Robert D SandersUniversity of Sydney, Sydney, NSW, Australia; Department of Anaesthetics, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. Electronic address: robert.sanders@sydney.edu.au.
University of Wisconsin–Madison · USUniversity of Gothenburg · SEIndiana University – Purdue University Indianapolis · USUniversity of Sydney · AU

Funding

Clarifying the overlapping pathology of delirium and dementiaR01AG063849 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Richard C Lennertz, Robert D Sanders · 2019 to 2026
$5.0M
The Cognitive Disintegration Model of Delirium: A Clinical Cohort Study Investigating Neural Network Connectivity and Local Slow Wave ActivityK23AG055700 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SANDERS, ROBERT D · 2018 to 2020
$483k
NIA NIH HHS K23 AG055700NIA NIH HHS R01 AG063849
6 · The paper itself

Abstract

backgroundPostoperative delirium is associated with increases in the neuronal injury biomarker, neurofilament light (NfL). Here we tested whether two other biomarkers, glial fibrillary acidic protein (GFAP) and tau, are associated with postoperative delirium.

methodsA total of 114 surgical patients were recruited into two prospective biomarker cohort studies with assessment of delirium severity and incidence. Plasma samples were sent for biomarker analysis including tau, NfL, and GFAP, and a panel of 10 cytokines. We determined a priori to adjust for interleukin-8 (IL-8), a marker of inflammation, when assessing associations between biomarkers and delirium incidence and severity.

resultsGFAP concentrations showed no relationship to delirium. The change in tau from preoperative concentrations to postoperative Day 1 was greater in patients with postoperative delirium (P<0.001) and correlated with delirium severity (ρ=0.39, P<0.001). The change in tau correlated with increases in IL-8 (P<0.001) and IL-10 (P=0.0029). Linear regression showed that the relevant clinical predictors of tau changes were age (P=0.037), prior stroke/transient ischaemic attack (P=0.001), and surgical blood loss (P<0.001). After adjusting for age, sex, preoperative cognition, and change in IL-8, tau remained significantly associated with delirium severity (P=0.026). Using linear mixed effect models, only tau (not NfL or IL-8) predicted recovery from delirium (P<0.001).

conclusionsThe change in plasma tau was associated with delirium incidence and severity, and resolved over time in parallel with delirium features. The impact of this putative perioperative neuronal injury biomarker on long-term cognition merits further investigation. CLINICAL

trial registrationNCT02926417 and NCT03124303.

Indexed as

AgedBiomarkersDeliriumFemaleGlial Fibrillary Acidic ProteinHumansIncidenceInterleukin-8MalePostoperative ComplicationsPredictive Value of TestsProspective StudiesSeverity of Illness Indextau ProteinsTime FactorsBiomarkersCXCL8 protein, humanGFAP protein, humanGlial Fibrillary Acidic ProteinInterleukin-8MAPT protein, humantau Proteinsbiomarkerdeliriumglial fibrillary acidic proteininflammationneuronal injurypostoperativesurgerytau

Identifiers

PMID33228978
PMCPMC8014913
OpenAlexW3105165665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.