ArticleAllergy2021
Identification of Pru du 6 as a potential marker allergen for almond allergy.
Article in Allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- A Review of Allergen Characteristics from Major Plant Allergenic Foods.Foods (Basel, Switzerland) · 2026Review
- Identification, Characterization and Epitopes Prediction of an Almond Allergen Pru du 8 Fragment.International journal of molecular sciences · 2026Article
- Almond Allergy in Children and Adults: A Narrative Review of Current Knowledge, Clinical Challenges, and Research Gaps.Nutrients · 2026Review
- Review
- Prospects for developing allergen-depleted food crops.The plant genome · 2023Review
- Microfluidic Analysis for the Determination of Protein Content in Different Types of Plant-Based Drinks.Molecules (Basel, Switzerland) · 2023Article
- Effects of protease-assisted aqueous extraction on almond protein profile, digestibility, and antigenicity.Current research in food science · 2023Article
- Pru du 1, the BetClinical and translational allergy · 2022Article
- Recent advances in diagnosing and managing nut allergies with focus on hazelnuts, walnuts, and cashew nuts.The World Allergy Organization journal · 2022Review
- Structure, Immunogenicity, and IgE Cross-Reactivity among Walnut and Peanut Vicilin-Buried Peptides.Journal of agricultural and food chemistry · 2022Article
- Identification of vicilin, legumin and antimicrobial peptide 2a as macadamia nut allergens.Food chemistry · 2022Article
- Newly defined allergens in the WHO/IUIS Allergen Nomenclature Database during 01/2019-03/2021.Allergy · 2021Review
- Aptamer-Based Fluorescent Biosensor for the Rapid and Sensitive Detection of Allergens in Food Matrices.Foods (Basel, Switzerland) · 2021Review
- Revalorization of Almond By-Products for the Design of Novel Functional Foods: An Updated Review.Foods (Basel, Switzerland) · 2021Review
- Article
- From Allergen Molecules to Molecular Immunotherapy of Nut Allergy: A Hard Nut to Crack.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral food challenges have demonstrated that diagnosis of almond allergy based on extract-sIgE tests displays low specificity. Molecular allergy diagnosis is expected to improve accuracy, but its value in diagnosing almond allergy remains unknown. The aim of this study was to identify relevant almond allergens and examine their ability to improve almond allergy diagnosis.
methodsIgE-reactive proteins were purified from almond kernels. IgE binding to almond extract and the allergens was analyzed by quantitative ELISA using sera from 18 subjects with a proven almond allergy. The control group consisted of sera from 18 subjects allergic to peanut and/or tree nuts but tolerant to almond.
resultsThree IgE-binding proteins were identified: legumin (Pru du 6), alpha-hairpinin (Pru du 8), and mandelonitrile lyase (Pru du 10). Positive IgE (≥0.35 kU/L) to almond extract showed 94% sensitivity but only 33% specificity. IgE to Pru du 6 maintained high sensitivity (83%) and provided superior specificity (78%). Sera from almond-allergic subjects had significantly higher IgE levels to almond extract (P < .0001) and Pru du 6 (P < .0001) than sera from tolerant donors. Sensitization to Pru du 6 was highly specific for almond allergy, while frequencies of sensitization to legumins from peanut, walnut, hazelnut, and cashew were similar in both groups. IgE to Pru du 8 and Pru du 10 was less sensitive (41% and 67%), but showed specificities of 100% and 61%.
conclusionThe use of almond allergens markedly increases the diagnostic specificity compared to the extract. Pru du 6 is a potential new molecular marker for almond allergy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.