ArticleJournal of neural engineering2020
Activated iridium oxide film (AIROF) electrodes for neural tissue stimulation.
Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Wafer-Scale Dendritic Nanoporous Platinum Films for Neural Electrodes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A fully implantable intraspinal microstimulation device for early preclinical evaluation of feasibility, stability, and functionality.Scientific reports · 2026Article
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- Electrochemical characterization and chronic stability of Utah electrode arrays for intracortical microstimulation.Frontiers in neuroscience · 2026Article
- The Role of Scalp EEG Recordings During Cortical Visual Prosthesis Testing.Artificial organs · 2025Article
- Fabrication and Dose-Response Simulation of Soft Dual-Sided Deep Brain Stimulation Electrode.Micromachines · 2025Article
- Stability of sputtered iridium oxide neural microelectrodes under kilohertz frequency pulsed stimulation.Journal of neural engineering · 2024Article
- Bioelectronic Neural Interfaces: Improving Neuromodulation Through Organic Conductive Coatings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies.Frontiers in integrative neuroscience · 2024Review
- Electrocatalytic on-site oxygenation for transplanted cell-based-therapies.Nature communications · 2023Article
- Direct laser writing of 3D electrodes on flexible substrates.Nature communications · 2023Article
- Chronic Stability of Local Field Potentials Using Amorphous Silicon Carbide Microelectrode Arrays Implanted in the Rat Motor Cortex.Micromachines · 2023Article
- Flexible IrOActa biomaterialia · 2023Article
- Plasma-Assisted Atomic Layer Deposition of IrONanomaterials (Basel, Switzerland) · 2023Article
- Clinical Progress and Optimization of Information Processing in Artificial Visual Prostheses.Sensors (Basel, Switzerland) · 2022Review
- Wireless microelectrode arrays for selective and chronically stable peripheral nerve stimulation for hindlimb movement.Journal of neural engineering · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveIridium oxide films are commonly used as a high charge-injection electrode material in neural devices. Yet, few studies have performed in-depth assessments of material performance versus film thickness, especially for films grown on three-dimensional (instead of planar) metal surfaces in neutral pH electrolyte solutions. Further, few studies have investigated the driving voltage requirements for constant-current stimulation using activated iridium oxide (AIROF) electrodes, which will be a key constraint for future use in wirelessly powered neural devices. APPROACH: In this study, iridium microwire probes were activated by repeated potential pulsing in room temperature phosphate buffered saline (pH 7.1-7.3). Electrochemical measurements were recorded in three different electrolyte conditions for probes with different geometric surface areas (GSAs) as the AIROF thickness was increased. MAIN
resultsMaintaining an anodic potential bias during the inter-pulse interval was required for AIROF electrodes to deliver charge levels considered necessary for neural stimulation. Potential pulsing for 100-200 cycles was sufficient to achieve charge injection levels of 2.5 mC cm SIGNIFICANCE: This study establishes methods for choosing an activation protocol and a desired GSA for three-dimensional iridium electrodes suitable for neural tissue insertion and stimulation, and provides guidelines for evaluating electrochemical performance of AIROF using model saline solutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.