Evidence map›Paper›PMID 32822617›Full record

ReviewCell chemical biology2020

Chemical Biology Tools for Examining the Bacterial Cell Wall.

Ashley R Brown, Rebecca A Gordon, Stephen N Hyland, M Sloan Siegrist, Catherine L Grimes

Abstract readReview
In one paragraph

Review in Cell chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Review
  3. International journal of systematic and evolutionary microbiology · 2025
    Article
  4. Article
  5. Chemical biology tools to probe bacterial glycans.Current opinion in chemical biology · 2024
    Review
  6. Minimalist TetrazineJournal of the American Chemical Society · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Overview on Strategies and Assays for Antibiotic Discovery.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashley R BrownDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Rebecca A GordonDepartment of Microbiology, University of Massachusetts, Amherst, MA 01003-9298, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst 01003-9298, USA.
Stephen N HylandDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
M Sloan SiegristDepartment of Microbiology, University of Massachusetts, Amherst, MA 01003-9298, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst 01003-9298, USA.
Catherine L GrimesDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA; Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA. Electronic address: cgrimes@udel.edu.

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Chemical detection of Mycobacterium tuberculosis growth and antibiotic response during infectionDP2AI138238 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI SIEGRIST, MARY SLOAN · 2017 to 2017
$2.3M
Metabolic carbohydrate cell wall probes for bacterial structure and immune recognition studiesU01CA221230 · NCI · UNIVERSITY OF DELAWARE · PI GRIMES, CATHERINE LEIMKUHLER · 2017 to 2019
$1.1M
Spatial organization of mycobacterial cell wall biosynthesisR21AI144748 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MORITA, YASU S, SIEGRIST, MARY SLOAN · 2019 to 2020
$423k
NCI NIH HHS U01 CA221230NIAID NIH HHS DP2 AI138238NIAID NIH HHS R21 AI144748NIGMS NIH HHS P20 GM104316NIGMS NIH HHS T32 GM008515NIGMS NIH HHS T32 GM133395
6 · The paper itself

Abstract

Bacteria surround themselves with cell walls to maintain cell rigidity and protect against environmental insults. Here we review chemical and biochemical techniques employed to study bacterial cell wall biogenesis. Recent advances including the ability to isolate critical intermediates, metabolic approaches for probe incorporation, and isotopic labeling techniques have provided critical insight into the biochemistry of cell walls. Fundamental manuscripts that have used these techniques to discover cell wall-interacting proteins, flippases, and cell wall stoichiometry are discussed in detail. The review highlights that these powerful methods and techniques have exciting potential to identify and characterize new targets for antibiotic development.

Indexed as

Anti-Bacterial AgentsBacteriaBacterial ProteinsCell WallIsotope LabelingMagnetic Resonance SpectroscopyPeptidoglycanPhospholipid Transfer ProteinsSmall Molecule LibrariesAnti-Bacterial AgentsBacterial ProteinsPeptidoglycanPhospholipid Transfer ProteinsSmall Molecule Librariesantibioticsbacterial cell envelopebacterial cell wallbiochemical probesmetabolic engineeringpeptidoglycan biosynthesisphotocrosslinkingradiolabeling

Identifiers

PMID32822617
PMCPMC7590259

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.