Evidence map›Paper›PMID 32574269›Full record

ArticleFrontiers in immunology2020

Could SARS-CoV-2-Induced Hyperinflammation Magnify the Severity of Coronavirus Disease (CoViD-19) Leading to Acute Respiratory Distress Syndrome?

A S Smiline Girija, Esaki M Shankar, Marie Larsson

Abstract readComment
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. MEFV gene variations in COVID-19 pneumonia patients (Pilot study).Journal, genetic engineering & biotechnology · 2025
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  13. Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-κB signal responses.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

A S Smiline GirijaDepartment of Microbiology, Saveetha Dental College and Hospitals, Chennai, India.
Esaki M ShankarInfection Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.
Marie LarssonMolecular Medicine and Virology, Department of Biomedicine and Clinical Sciences, Linköping University, Linköping, Sweden.

Funding

Innate NKT Cells in HIV InfectionR37AI052731 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NIXON, DOUGLAS F · 2007 to 2016
$3.1M
Innate NKT Cells in HIV InfectionR01AI052731 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NIXON, DOUGLAS F · 2002 to 2006
$2.1M
NIAID NIH HHS R01 AI052731NIAID NIH HHS R37 AI052731
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CoronavirusRespiratory Distress SyndromeSevere acute respiratory syndrome-related coronavirusBetacoronavirusChinaCoronavirus InfectionsCOVID-19HumansPandemicsPneumonia, ViralSARS-CoV-2corona virus disease 2019cytokine stormIL-1βIL-6TNF-α

Identifiers

PMID32574269
PMCPMC7267050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.