Evidence map›Paper›PMID 32517288›Full record

ArticleMicroorganisms2020

Flavonoids from Mulberry Leaves Alleviate Lipid Dysmetabolism in High Fat Diet-Fed Mice: Involvement of Gut Microbiota.

Yinzhao Zhong, Bo Song, Changbing Zheng, Shiyu Zhang, Zhaoming Yan, Zhiyi Tang, Xiangfeng Kong, Yehui Duan, Fengna Li

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Mulberry (Animals : an open access journal from MDPI · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Exogenous spraying of 4-chlorophenoxyacetic acid sodium salt promotes growth and flavonoid biosynthesis of mulberry leaves (Physiology and molecular biology of plants : an international journal of functional plant biology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Effects ofFrontiers in pharmacology · 2022
    Article
  18. Frontiers in nutrition · 2022
    Article
  19. Dietary supplementation withFrontiers in immunology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yinzhao ZhongHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process; CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; Hunan Provincial Engineeritng Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha 410125, China.
Bo SongHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process; CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; Hunan Provincial Engineeritng Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha 410125, China.
Changbing ZhengGuangdong Provincial Key Laboratory of Animal Nutrition Regulation, South China Agricultural University, Guangzhou 510642, China.
Shiyu ZhangCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Zhaoming YanCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Zhiyi TangCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Xiangfeng KongHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process; CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; Hunan Provincial Engineeritng Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha 410125, China.
Yehui DuanHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process; CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; Hunan Provincial Engineeritng Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha 410125, China.ORCID 0000-0002-6131-2855
Fengna LiHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process; CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; Hunan Provincial Engineeritng Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha 410125, China.ORCID 0000-0002-0040-9784
Chinese Academy of Sciences · CNHunan Agricultural University · CNSouth China Agricultural University · CN

Funding

Earmarked Fund for China Agriculture Research System CARS-35National Natural Science Foundation of China 31802077, U19A2037, 31972582Science and Technology Project of Guangxi Province 2018JJB130239STS regional key project of the Chinese Academy of Sciences KFJ-STS-QYZD-052
6 · The paper itself

Abstract

Here, we investigated the roles and mechanisms of flavonoids from mulberry leaves (FML) on lipid metabolism in high fat diet (HFD)-fed mice. ICR mice were fed either a control diet (Con) or HFD with or without FML (240 mg/kg/day) by oral gavage for six weeks. FML administration improved lipid accumulation, alleviated liver steatosis and the whitening of brown adipose tissue, and improved gut microbiota composition in HFD-fed mice. Microbiota transplantation from FML-treated mice alleviated HFD-induced lipid metabolic disorders. Moreover, FML administration restored the production of acetic acid in HFD-fed mice. Correlation analysis identified a significant correlation between the relative abundances of

Indexed as

acetic acidFMLgut microbiotalipid metabolismmicrobiota transplantation

Identifiers

PMID32517288
PMCPMC7355566
OpenAlexW3034112508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.