ArticleLipids in health and disease2020
Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states.
Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.
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Who cites it
81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Pooled it
- Hypertriglyceridemia is a dose-dependent risk factor for type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Maternal metabolic factors and the association with gestational diabetes: A systematic review and meta-analysis.Diabetes/metabolism research and reviews · 2022Pooled it
- Bridging Glycemic and Lipid Control: Effects of Dapagliflozin in Co-Morbid Diabetes and Heart Failure – A Randomized Controlled TrialEndocrine, metabolic & immune disorders drug targets · 2026Trial
- Effect of intermittent versus continuous calorie restriction on body weight and cardiometabolic risk markers in subjects with overweight or obesity and mild-to-moderate hypertriglyceridemia: a randomized trial.Lipids in health and disease · 2020Trial
- High-Value Utilization of Coconut Kernel Fiber By-Products: The Insulin-Sensitizing Effect of Novel α-Glucosidase-Inhibiting Peptides Derived from Coconut Kernel Fiber on T2DM Mice.Foods (Basel, Switzerland) · 2026Article
- Association between serum chemerin and breast cancer mediated by lipid metabolism.Discover oncology · 2026Article
- Gastrodin Ameliorates Type II Diabetes Through the YY1-FXR-Bile Acid Axis.International journal of molecular sciences · 2026Article
- Triglycerides and HDL cholesterol as strong correlates of insulin resistance: Evidence from NHANES 2013 to 2018.Medicine · 2026Article
- Article
- Review on the Relationship Between TyG Index and CVD Incidence in Patients With T2DM With NAFLD.International journal of endocrinology · 2026Review
- Correlation between TyG index, TyG-BMI index and AIP index and early-onset type 2 diabetic nephropathy.Frontiers in endocrinology · 2026Article
- Foot-and-mouth disease adversely affects energy metabolism, surrogate indices of insulin resistance and milk yield till day 180 post-infection in the dairy cow.Tropical animal health and production · 2025Article
- Enhanced oral glucose tolerance test for early detection of insulin resistance and metabolic complications in children with obesity.American journal of preventive cardiology · 2025Article
- The Acute Effects of Morning Bright Light on the Human White Adipose Tissue Transcriptome: Exploratory Post Hoc Analysis.Clocks & sleep · 2025Article
- Accelerated increase in ferritin levels during menopausal transition as a marker of metabolic health.Scientific reports · 2025Article
- Correlation of Triglyceride-Glucose Index and the Presence of Microvascular Complications of Diabetes.Cureus · 2025Article
- Association between remnant cholesterol and low-density lipoprotein cholesterol discordance and type 2 diabetes or prediabetes: results from NHANES.BMC endocrine disorders · 2025Article
- Effectiveness of a theory-based tailored individual and family self-management education in adults with uncontrolled diabetes: A randomized controlled trial.International journal of nursing sciences · 2025Article
- Triglyceride-glycated hemoglobin index as a superior predictor of type 2 diabetes risk in a large-scale retrospective cohort study.Scientific reports · 2025Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies on the effects of lipotoxicity and oxidative stress on islet beta cell function mainly focused on patients with diabetes, whereas studies on normal glucose tolerance (NGT) are few. The aim of this study was to explore the relationships among triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), oxidative stress indicators, insulin resistance, and beta cell function in populations with different glucose and lipid metabolism states.
methodsA total of 517 individuals were recruited from a rural community in Beijing, China. Glucose metabolism status was defined according to the results of a 75-g oral glucose tolerance test (OGTT). Dyslipidemia was defined as abnormal TG, HDL-c, or LDL-c levels. The population was divided into four groups: individuals with normal glucose and lipid levels (group A, n = 62); those with dyslipidemia alone (group B, n = 82); those with dysglycemia alone (group C, n = 121); and those with dysglycemia and dyslipidemia (group D, n = 247). Oxidative stress indicators, including superoxide dismutase (SOD), glutathione reductase (GR) and 8-hydroxydeoxyguanosine (8-OHdG), were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) and glucose disposition index (DI
resultsCompared with the control group, populations with dyslipidemia and/or dysglycemia showed significantly increased insulin resistance. Dyslipidemia aggravated insulin resistance and beta cell dysfunction in individuals with dysglycemia. Stratified regression analysis showed that TG positively correlated with LnHOMA-IR in individuals with normal glucose levels (beta = 0.321, 0.327, P = 0.011, 0.003 in groups A and B, respectively) and negatively correlated with LnDI
conclusionTG correlated with both insulin resistance and beta cell function in individuals with dyslipidemia alone. SOD negatively correlated with TG, indicating a close relationship between oxidative stress and glucose-lipid metabolism. Due to the adverse effect of hypertriglyceridemia on insulin sensitivity and islet beta cell function, more attention should be paid to the detection and management of hypertriglyceridemia.
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