ArticleJournal of the American Heart Association2020
Dietary Intakes of Eggs and Cholesterol in Relation to All-Cause and Heart Disease Mortality: A Prospective Cohort Study.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Substitution of animal-based with plant-based foods on cardiometabolic health and all-cause mortality: a systematic review and meta-analysis of prospective studies.BMC medicine · 2023Pooled it
- Egg Consumption and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-analysis of Prospective Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Pooled it
- Egg and Dietary Cholesterol Intake and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.Frontiers in nutrition · 2022Pooled it
- Dietary protein density, cholesterol, egg consumption and mortality in US adults with type 2 diabetes: A prospective cohort study.Medicine · 2026Article
- Microwave and solvent extraction ofFood chemistry: X · 2026Article
- Conjoint association of gestational diabetes mellitus and hypertensive disorders of pregnancy with long-term risk of mortality: a population-based cohort study.Journal of global health · 2026Article
- Dietary cholesterol intake and egg consumption in relation to all-cause and cardiovascular mortality after stroke.Scientific reports · 2025Article
- Egg Consumption and Mortality: A Prospective Cohort Study of Australian Community-Dwelling Older Adults.Nutrients · 2025Article
- Gut microbes, diet, and genetics as drivers of metabolic liver disease: a narrative review outlining implications for precision medicine.The Journal of nutritional biochemistry · 2024Review
- Association of sensitivity to thyroid hormones with all-cause mortality in euthyroid US adults: A nationwide cohort study.European thyroid journal · 2024Article
- Egg consumption and risk of cardiovascular disease: a PERSIAN cohort-based study.BMC cardiovascular disorders · 2023Article
- Eggs and Cardiovascular Disease Risk: An Update of Recent Evidence.Current atherosclerosis reports · 2023Review
- The Impact of Dietary Cholesterol on Low-Density Lipoprotein: Lessons in Absorption and Overconsumption.JCEM case reports · 2023Article
- Frequency of Egg Intake Associated with Mortality in Chinese Adults: An 8-Year Nationwide Cohort Study.International journal of environmental research and public health · 2022Article
- Vegan Egg: A Future-Proof Food Ingredient?Foods (Basel, Switzerland) · 2022Review
- Assessment of Consumers' Perception of Chicken Eggs Consumption and Associated Health Implications in the Volta Region of Ghana.Nutrition and metabolic insights · 2022Article
- Egg consumption and risk of all-cause and cause-specific mortality in an Italian adult population.European journal of nutrition · 2021Article
- Cholesterol and Egg Intakes with Cardiometabolic and All-Cause Mortality among Chinese and Low-Income Black and White Americans.Nutrients · 2021Article
- Dietary habits of patients with coronary artery disease in a tertiary-care hospital of Bangladesh: a case-controlled study.Journal of health, population, and nutrition · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The aim of this study was to identify associations between dietary intakes of eggs and cholesterol and all-cause and heart disease mortality in a US population. Methods and Results Data from the National Health and Nutrition Examination Survey 1999-2014 were used in this study, which included 37 121 participants ≥20 years of age. Dietary information was assessed via 24-hour dietary recalls at baseline. Mortality status was documented until December 31, 2015. Cox proportional hazards models were used to examine the associations between dietary intakes of eggs and cholesterol and all-cause and heart disease mortality. During a median follow-up of 7.8 years, 4991 deaths were documented, including 870 deaths from heart disease. No significant association was observed between additional daily consumption of half an egg and all-cause mortality (multivariable-adjusted hazard ratio, 1.04; 95% CI, 0.96-1.13), or heart disease mortality (0.96; 0.80-1.14). Each 50-mg/day increase of cholesterol intake was inversely associated with all-cause mortality among participants with daily intake <250 mg (0.87; 0.77-0.98), but positively associated with all-cause mortality among participants with daily intake ≥250 mg (1.07; 1.01-1.12). No significant association was found between dietary cholesterol intake and heart disease mortality. Conclusions No significant association was found between egg consumption and mortality in US adults. The association between dietary cholesterol intake and all-cause mortality depended on the baseline intake levels, with an inverse association in those with lower intake levels (<250 mg/day) but a positive association in those with higher intake levels (≥250 mg/day).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.